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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF4

Summary for RNF4

Gene information	Gene symbol	RNF4
	Ensembl ID	ENSG00000063978
	Entrez ID	6047
	Gene name	ring finger protein 4
	Synonyms	RES4-26\|SLX5\|SNURF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RNF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.407616	0.00e+00

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Expression of RNF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF4	hsa-miR-3173-5p	91.6856	NM_001185010
RNF4	hsa-miR-4261	91.61	NM_001185009
RNF4	hsa-miR-3664-3p	90.9516	NM_001185009
RNF4	hsa-miR-4325	90.3861	NM_001185010
RNF4	hsa-miR-3671	90.0335	NM_001185010
RNF4	hsa-miR-137-3p	89.6869	NM_001185010
RNF4	hsa-miR-6799-3p	89.4914	NM_001185010
RNF4	hsa-miR-92b-3p	89.4462	NM_001185010
RNF4	hsa-miR-92a-3p	89.4462	NM_001185010
RNF4	hsa-miR-32-5p	89.4462	NM_001185010
RNF4	hsa-miR-607	89.2699	NM_001185010
RNF4	hsa-miR-379-3p	88.479	NM_001185009
RNF4	hsa-miR-411-3p	88.479	NM_001185009
RNF4	hsa-miR-361-5p	88.13	NM_001185010
RNF4	hsa-miR-367-3p	87.9196	NM_001185010
RNF4	hsa-miR-363-3p	87.9196	NM_001185010
RNF4	hsa-miR-25-3p	87.9196	NM_001185010
RNF4	hsa-miR-1910-3p	87.025	NM_001185010
RNF4	hsa-miR-3685	87.0201	NM_001185010
RNF4	hsa-miR-6511a-5p	86.7096	NM_001185010
RNF4	hsa-miR-3147	86.3634	NM_001185010
RNF4	hsa-miR-659-3p	86.1748	NM_001185009
RNF4	hsa-miR-155-3p	86.0115	NM_001185010
RNF4	hsa-miR-4448	85.9442	NM_001185010
RNF4	hsa-miR-4753-5p	85.7753	NM_001185010
RNF4	hsa-miR-3612	85.6881	NM_001185010
RNF4	hsa-miR-650	85.6881	NM_001185010
RNF4	hsa-miR-4443	85.3219	NM_001185009
RNF4	hsa-miR-147b-5p	85.0897	NM_001185009
RNF4	hsa-miR-205-5p	84.3787	NM_001185010
RNF4	hsa-miR-2115-3p	83.9341	NM_001185010
RNF4	hsa-miR-5688	83.8335	NM_001185009
RNF4	hsa-miR-222-3p	83.4022	NM_001185009
RNF4	hsa-miR-221-3p	83.4022	NM_001185009
RNF4	hsa-miR-493-5p	83.3908	NM_001185010
RNF4	hsa-miR-1302	83.285	NM_001185009
RNF4	hsa-miR-4427	82.6909	NM_001185010
RNF4	hsa-miR-4324	82.4995	NM_001185010
RNF4	hsa-miR-4298	82.1837	NM_001185009
RNF4	hsa-miR-374a-3p	80.5949	NM_001185010

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Motifs and transcription factors (TFs) regulating RNF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RNF4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RNF4	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RNF4	jaspar__MA1483.2	ELF2 (directAnnotation).
RNF4	transfac_pro__M04826	EP300 (directAnnotation).
RNF4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RNF4	hdpi__ETV4	ETV4 (directAnnotation).
RNF4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RNF4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."