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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF216

Summary for RNF216

Gene information	Gene symbol	RNF216
	Ensembl ID	ENSG00000011275
	Entrez ID	54476
	Gene name	ring finger protein 216
	Synonyms	TRIAD3\|UBCE7IP1\|ZIN
	Gene type	protein_coding
	UniProtAcc	Q9NWF9

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Dataset with differentially expressed gene: RNF216

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.250106	1.29e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.287065	7.13e-42

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Expression of RNF216 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF216

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF216

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF216	hsa-miR-130b-3p	94.9597	NM_207111
RNF216	hsa-miR-454-3p	94.9597	NM_207111
RNF216	hsa-miR-4295	94.9597	NM_207111
RNF216	hsa-miR-130a-3p	94.9597	NM_207111
RNF216	hsa-miR-301a-3p	94.9597	NM_207111
RNF216	hsa-miR-301b-3p	94.9597	NM_207111
RNF216	hsa-miR-3666	94.8145	NM_207111
RNF216	hsa-miR-7856-5p	94.2052	NM_207111
RNF216	hsa-miR-3941	94.11	NM_207111
RNF216	hsa-miR-6764-5p	93.6754	NM_207116
RNF216	hsa-miR-6132	92.4269	NM_207116
RNF216	hsa-miR-6836-5p	92.4269	NM_207116
RNF216	hsa-miR-8485	91.9779	NM_207111
RNF216	hsa-miR-3714	91.6494	NM_207111
RNF216	hsa-miR-5580-3p	90.8096	NM_207111
RNF216	hsa-miR-4672	90.6532	NM_207111
RNF216	hsa-miR-519a-3p	90.5757	NM_207111
RNF216	hsa-miR-519c-3p	90.5757	NM_207111
RNF216	hsa-miR-519b-3p	90.5757	NM_207111
RNF216	hsa-miR-1915-3p	90.3849	NM_207116
RNF216	hsa-let-7f-1-3p	90.1525	NM_207111
RNF216	hsa-miR-98-3p	90.1525	NM_207111
RNF216	hsa-let-7b-3p	90.1525	NM_207111
RNF216	hsa-let-7a-3p	90.1525	NM_207111
RNF216	hsa-miR-6882-3p	89.7925	NM_207116
RNF216	hsa-miR-302e	87.6048	NM_207111
RNF216	hsa-miR-466	87.4132	NM_207111
RNF216	hsa-miR-4477b	85.7977	NM_207111
RNF216	hsa-miR-10524-5p	85.713	NM_207116
RNF216	hsa-miR-520g-3p	85.2791	NM_207111
RNF216	hsa-miR-520h	85.2791	NM_207111
RNF216	hsa-miR-6852-5p	84.417	NM_207116
RNF216	hsa-miR-1207-5p	84.3612	NM_207116
RNF216	hsa-miR-19b-3p	84.2988	NM_207111
RNF216	hsa-miR-19a-3p	84.2988	NM_207111
RNF216	hsa-miR-4729	83.8907	NM_207111
RNF216	hsa-miR-302a-3p	83.2646	NM_207111
RNF216	hsa-miR-302d-3p	83.2646	NM_207111
RNF216	hsa-miR-302c-3p	83.2646	NM_207111
RNF216	hsa-miR-302b-3p	83.2646	NM_207111
RNF216	hsa-miR-520d-5p	82.2763	NM_207111
RNF216	hsa-miR-524-5p	82.2763	NM_207111
RNF216	hsa-miR-4639-5p	82.1175	NM_207111
RNF216	hsa-miR-373-3p	81.5907	NM_207111
RNF216	hsa-miR-520c-3p	81.5907	NM_207111
RNF216	hsa-miR-520e-3p	81.5907	NM_207111
RNF216	hsa-miR-372-3p	81.5907	NM_207111
RNF216	hsa-miR-520d-3p	81.5907	NM_207111
RNF216	hsa-miR-520b-3p	81.5907	NM_207111
RNF216	hsa-miR-520a-3p	81.5907	NM_207111

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Motifs and transcription factors (TFs) regulating RNF216

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF216	metacluster_7.13	ZFX (directAnnotation).
RNF216	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RNF216	metacluster_151.2	ZNF23 (directAnnotation).
RNF216	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RNF216	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RNF216	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RNF216	hdpi__ETV4	ETV4 (directAnnotation).
RNF216	transfac_pro__M05628	ZNF735 (directAnnotation).
RNF216	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RNF216	transfac_pro__M01253	CNOT3 (directAnnotation).
RNF216	transfac_pro__M04817	ZBTB33 (directAnnotation).
RNF216	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."