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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF214

Summary for RNF214

Gene information	Gene symbol	RNF214
	Ensembl ID	ENSG00000167257
	Entrez ID	257160
	Gene name	ring finger protein 214
	Synonyms	DKFZp547C195
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RNF214

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.891718	1.89e-02

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Expression of RNF214 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF214

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF214

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF214	hsa-miR-20a-3p	97.8278	NM_001278249
RNF214	hsa-miR-544a	93.7809	NM_001278249
RNF214	hsa-miR-568	92.1619	NM_001278249
RNF214	hsa-miR-942-3p	91.3611	NM_001077239
RNF214	hsa-miR-374a-5p	90.521	NM_001077239
RNF214	hsa-miR-374b-5p	90.521	NM_001077239
RNF214	hsa-miR-3922-5p	89.8226	NM_001077239
RNF214	hsa-miR-1266-3p	88.8075	NM_001278249
RNF214	hsa-miR-5692b	88.0576	NM_001077239
RNF214	hsa-miR-5692c	88.0576	NM_001077239
RNF214	hsa-miR-1284	86.9337	NM_001278249
RNF214	hsa-miR-4778-3p	84.4585	NM_001077239
RNF214	hsa-miR-369-3p	83.981	NM_001077239
RNF214	hsa-miR-499b-5p	83.5399	NM_001278249
RNF214	hsa-miR-3663-3p	81.9667	NM_001077239

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Motifs and transcription factors (TFs) regulating RNF214

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."