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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF2

Summary for RNF2

Gene information	Gene symbol	RNF2
	Ensembl ID	ENSG00000121481
	Entrez ID	6045
	Gene name	ring finger protein 2
	Synonyms	BAP-1\|BAP1\|DING\|HIPI3\|RING1B\|RING2
	Gene type	protein_coding
	UniProtAcc	Q99496

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Dataset with differentially expressed gene: RNF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.260223	0.00e+00

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Expression of RNF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RNF2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RNF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF2	hsa-miR-3148	99.4883	NM_007212
RNF2	hsa-miR-4668-5p	99.348	NM_007212
RNF2	hsa-miR-3662	98.1113	NM_007212
RNF2	hsa-miR-3660	96.549	NM_007212
RNF2	hsa-miR-4526	96.549	NM_007212
RNF2	hsa-miR-3613-3p	96.0502	NM_007212
RNF2	hsa-miR-922	95.7784	NM_007212
RNF2	hsa-miR-149-5p	94.6781	NM_007212
RNF2	hsa-miR-302d-5p	94.1355	NM_007212
RNF2	hsa-miR-302b-5p	94.1355	NM_007212
RNF2	hsa-miR-6819-5p	93.5912	NM_007212
RNF2	hsa-miR-6737-5p	93.5912	NM_007212
RNF2	hsa-miR-3143	93.5573	NM_007212
RNF2	hsa-miR-6812-5p	92.6424	NM_007212
RNF2	hsa-miR-200c-3p	92.391	NM_007212
RNF2	hsa-miR-429	92.391	NM_007212
RNF2	hsa-miR-200b-3p	92.391	NM_007212
RNF2	hsa-miR-889-3p	92.3661	NM_007212
RNF2	hsa-miR-24-3p	91.8677	NM_007212
RNF2	hsa-miR-3163	91.5754	NM_007212
RNF2	hsa-miR-4693-5p	91.2468	NM_007212
RNF2	hsa-miR-186-5p	90.8595	NM_007212
RNF2	hsa-miR-6824-3p	90.8185	NM_007212
RNF2	hsa-miR-6764-3p	90.8185	NM_007212
RNF2	hsa-miR-3133	90.7779	NM_007212
RNF2	hsa-miR-3912-5p	90.4106	NM_007212
RNF2	hsa-miR-4731-3p	90.3565	NM_007212
RNF2	hsa-miR-4801	89.9765	NM_007212
RNF2	hsa-miR-4474-3p	89.963	NM_007212
RNF2	hsa-miR-8060	89.6762	NM_007212
RNF2	hsa-miR-9902	89.6032	NM_007212
RNF2	hsa-miR-6783-3p	89.1976	NM_007212
RNF2	hsa-miR-1252-3p	89.0224	NM_007212
RNF2	hsa-miR-202-5p	88.8021	NM_007212
RNF2	hsa-miR-7856-5p	86.8054	NM_007212
RNF2	hsa-miR-12136	86.3361	NM_007212
RNF2	hsa-miR-302a-5p	86.3176	NM_007212
RNF2	hsa-miR-1284	86.2638	NM_007212
RNF2	hsa-miR-4291	85.9394	NM_007212
RNF2	hsa-miR-6797-3p	85.8723	NM_007212
RNF2	hsa-miR-1343-3p	85.4898	NM_007212
RNF2	hsa-miR-548ar-3p	84.8466	NM_007212
RNF2	hsa-miR-6749-3p	84.1162	NM_007212
RNF2	hsa-miR-10526-3p	83.8577	NM_007212
RNF2	hsa-miR-3688-3p	83.7619	NM_007212
RNF2	hsa-miR-5585-3p	83.6315	NM_007212
RNF2	hsa-miR-6076	83.4883	NM_007212
RNF2	hsa-miR-500a-5p	83.4454	NM_007212
RNF2	hsa-miR-548n	83.298	NM_007212
RNF2	hsa-miR-587	83.2821	NM_007212

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Motifs and transcription factors (TFs) regulating RNF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RNF2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RNF2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RNF2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RNF2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RNF2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RNF2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
RNF2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RNF2	transfac_pro__M00652	NRF1 (directAnnotation).
RNF2	hdpi__ETV4	ETV4 (directAnnotation).
RNF2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RNF2	transfac_pro__M04866	HDAC2 (directAnnotation).
RNF2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RNF2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RNF2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RNF2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RNF2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."