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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF19B

Summary for RNF19B

Gene information	Gene symbol	RNF19B
	Ensembl ID	ENSG00000116514
	Entrez ID	127544
	Gene name	ring finger protein 19B
	Synonyms	FLJ90005\|IBRDC3\|NKLAM
	Gene type	protein_coding
	UniProtAcc	Q6ZMZ0

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Dataset with differentially expressed gene: RNF19B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.700837	1.03e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.270213	1.65e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.37216	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.34702	1.96e-29

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Expression of RNF19B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF19B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF19B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF19B	hsa-miR-329-3p	94.0682	NM_001127361
RNF19B	hsa-miR-362-3p	94.0682	NM_001127361
RNF19B	hsa-miR-4490	93.1459	NM_001127361
RNF19B	hsa-miR-3941	91.4313	NM_001127361
RNF19B	hsa-miR-4436b-3p	91.0024	NM_001127361
RNF19B	hsa-miR-6879-5p	91.0024	NM_001127361
RNF19B	hsa-miR-4632-5p	91.0024	NM_001127361
RNF19B	hsa-miR-6735-5p	91.0024	NM_001127361
RNF19B	hsa-miR-7843-5p	91.0024	NM_001127361
RNF19B	hsa-miR-8485	89.3179	NM_001127361
RNF19B	hsa-miR-4292	89.0973	NM_001127361
RNF19B	hsa-miR-6791-5p	89.0973	NM_001127361
RNF19B	hsa-miR-3148	88.309	NM_153341
RNF19B	hsa-miR-95-5p	87.8073	NM_001127361
RNF19B	hsa-miR-4778-3p	86.4854	NM_001127361
RNF19B	hsa-miR-648	86.2136	NM_001127361
RNF19B	hsa-miR-219b-5p	85.4066	NM_001127361
RNF19B	hsa-miR-876-5p	85.381	NM_001127361
RNF19B	hsa-miR-514b-3p	84.1216	NM_001127361
RNF19B	hsa-miR-514a-3p	84.1216	NM_001127361
RNF19B	hsa-miR-5582-3p	83.2504	NM_001127361
RNF19B	hsa-miR-548ar-3p	83.2504	NM_001127361
RNF19B	hsa-miR-1179	82.355	NM_001127361
RNF19B	hsa-miR-587	82.0467	NM_001127361
RNF19B	hsa-miR-3167	81.2617	NM_001127361
RNF19B	hsa-miR-3163	80.7034	NM_001127361
RNF19B	hsa-miR-6830-3p	80.5261	NM_001127361

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Motifs and transcription factors (TFs) regulating RNF19B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF19B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RNF19B	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RNF19B	jaspar__MA1721.1	ZNF93 (directAnnotation).
RNF19B	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
RNF19B	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RNF19B	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
RNF19B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RNF19B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RNF19B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RNF19B	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RNF19B	transfac_pro__M01973	PLAG1 (directAnnotation).
RNF19B	metacluster_143.13	ZBTB7A (directAnnotation).
RNF19B	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RNF19B	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
RNF19B	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
RNF19B	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
RNF19B	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
RNF19B	transfac_pro__M01239	RELA (directAnnotation).
RNF19B	transfac_pro__M05707	ZNF239 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."