Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | 0.33812 | 4.70e-26 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | -0.391044 | 0.00e+00 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | -0.39347 | 4.13e-14 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | post | Malignant cells | 0.380571 | 1.82e-12 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | Malignant cells | 0.271015 | 6.09e-18 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | 0.502013 | 0.00e+00 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | 0.282549 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | -0.387761 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
RNF187 | jaspar__MA1106.1 | HIF1A (directAnnotation). |
RNF187 | taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP | ATF4; TEF (directAnnotation). |
RNF187 | taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP | ATF4; CEBPD (directAnnotation). |
RNF187 | metacluster_156.2 | ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology). |
RNF187 | taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP | ATF4; CEBPB (directAnnotation). |
RNF187 | kznf__ZNF384_Schmitges2016_RCADE | ZNF384 (directAnnotation). |
RNF187 | dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1 | GMEB1 (directAnnotation). |
RNF187 | tfdimers__MD00462 | SOX10; ZEB1 (directAnnotation). |
RNF187 | jaspar__MA1125.1 | ZNF384 (directAnnotation). |
RNF187 | metacluster_113.4 | MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology). |
RNF187 | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
RNF187 | taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr | ELK1; HOXB2 (directAnnotation). |
RNF187 | taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr | DLX3; ETV2 (directAnnotation). |
RNF187 | cisbp__M01863 | ZNF711 (inferredBy_Orthology). |
RNF187 | transfac_pro__M04950 | EGR1 (directAnnotation). |
RNF187 | taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr | ETV2; HES7 (directAnnotation). |
RNF187 | metacluster_7.7 | SP2 (directAnnotation). KLF16 (inferredBy_Orthology). |
RNF187 | taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr | HOXB2; PAX1 (directAnnotation). |
RNF187 | taipale_tf_pairs__HOXB2_PAX9_NNMATTAGTCACGCWTSRNTG_CAP | HOXB2; PAX9 (directAnnotation). |
RNF187 | transfac_pro__M02012 | HIF1A (directAnnotation). |
RNF187 | transfac_pro__M01249 | EPAS1 (directAnnotation). |
RNF187 | metacluster_55.5 | ZNF541 (directAnnotation). |
RNF187 | metacluster_71.2 | EPAS1 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |