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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF157

Summary for RNF157

Gene information	Gene symbol	RNF157
	Ensembl ID	ENSG00000141576
	Entrez ID	114804
	Gene name	ring finger protein 157
	Synonyms	KIAA1917
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RNF157

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.641608	0.00e+00

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Expression of RNF157 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF157

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF157

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF157	hsa-miR-4286	90.7693	NM_052916
RNF157	hsa-miR-664a-3p	89.5232	NM_052916
RNF157	hsa-miR-3658	89.4819	NM_052916
RNF157	hsa-miR-6722-3p	88.0925	NM_052916
RNF157	hsa-miR-3605-5p	88.0204	NM_052916
RNF157	hsa-miR-605-3p	87.3626	NM_052916
RNF157	hsa-miR-4779	86.2534	NM_052916
RNF157	hsa-miR-12123	86.1967	NM_052916
RNF157	hsa-miR-4476	86.1275	NM_052916
RNF157	hsa-miR-4328	85.7078	NM_052916
RNF157	hsa-miR-1909-3p	84.6292	NM_052916
RNF157	hsa-miR-2392	83.8381	NM_052916
RNF157	hsa-miR-6876-5p	83.3071	NM_052916
RNF157	hsa-miR-432-3p	82.4927	NM_052916
RNF157	hsa-miR-508-5p	81.9085	NM_052916
RNF157	hsa-miR-30c-5p	81.5867	NM_052916
RNF157	hsa-miR-30e-5p	81.5867	NM_052916
RNF157	hsa-miR-30a-5p	81.5867	NM_052916
RNF157	hsa-miR-30b-5p	81.5867	NM_052916
RNF157	hsa-miR-30d-5p	81.5867	NM_052916
RNF157	hsa-miR-4428	81.1054	NM_052916
RNF157	hsa-miR-4251	80.4037	NM_052916

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Motifs and transcription factors (TFs) regulating RNF157

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF157	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RNF157	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
RNF157	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RNF157	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RNF157	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RNF157	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RNF157	metacluster_3.14	WT1; WT1 (directAnnotation).
RNF157	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."