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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF149

Summary for RNF149

Gene information	Gene symbol	RNF149
	Ensembl ID	ENSG00000163162
	Entrez ID	284996
	Gene name	ring finger protein 149
	Synonyms	FLJ90504
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RNF149

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.371497	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.288379	9.07e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.411586	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.314794	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.292565	5.86e-34
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.427318	4.66e-41
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.364432	2.63e-22

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Expression of RNF149 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF149

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF149

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF149	hsa-miR-411-5p	96.6003	NM_173647
RNF149	hsa-miR-548ap-5p	93.8974	NM_173647
RNF149	hsa-miR-548bb-5p	93.8974	NM_173647
RNF149	hsa-miR-548o-5p	93.8974	NM_173647
RNF149	hsa-miR-548am-5p	93.8974	NM_173647
RNF149	hsa-miR-548w	93.8974	NM_173647
RNF149	hsa-miR-548ar-5p	93.8974	NM_173647
RNF149	hsa-miR-548ak	93.8974	NM_173647
RNF149	hsa-miR-548b-5p	93.8974	NM_173647
RNF149	hsa-miR-548i	93.8974	NM_173647
RNF149	hsa-miR-548h-5p	93.8974	NM_173647
RNF149	hsa-miR-548au-5p	93.8974	NM_173647
RNF149	hsa-miR-548d-5p	93.8974	NM_173647
RNF149	hsa-miR-548aq-5p	93.8974	NM_173647
RNF149	hsa-miR-548c-5p	93.8974	NM_173647
RNF149	hsa-miR-548a-5p	93.8974	NM_173647
RNF149	hsa-miR-548ay-5p	93.8974	NM_173647
RNF149	hsa-miR-548ae-5p	93.8974	NM_173647
RNF149	hsa-miR-548as-5p	93.8974	NM_173647
RNF149	hsa-miR-548j-5p	93.8974	NM_173647
RNF149	hsa-miR-548ab	93.8974	NM_173647
RNF149	hsa-miR-548ad-5p	93.8974	NM_173647
RNF149	hsa-miR-548y	93.8974	NM_173647
RNF149	hsa-miR-559	93.1151	NM_173647
RNF149	hsa-miR-196a-1-3p	91.9085	NM_173647
RNF149	hsa-miR-607	91.7668	NM_173647
RNF149	hsa-miR-8065	91.5099	NM_173647
RNF149	hsa-miR-577	90.5181	NM_173647
RNF149	hsa-let-7a-3p	87.5418	NM_173647
RNF149	hsa-miR-98-3p	87.5418	NM_173647
RNF149	hsa-let-7f-1-3p	87.5418	NM_173647
RNF149	hsa-let-7b-3p	87.5418	NM_173647
RNF149	hsa-miR-5584-3p	87.0703	NM_173647
RNF149	hsa-miR-3935	87.0397	NM_173647
RNF149	hsa-miR-4687-3p	86.7903	NM_173647
RNF149	hsa-miR-3973	86.551	NM_173647
RNF149	hsa-miR-6515-3p	86.0174	NM_173647
RNF149	hsa-miR-3186-5p	85.9381	NM_173647
RNF149	hsa-miR-2116-5p	85.2044	NM_173647
RNF149	hsa-miR-590-3p	85.0711	NM_173647
RNF149	hsa-miR-4422	82.2495	NM_173647
RNF149	hsa-miR-208a-5p	81.0203	NM_173647
RNF149	hsa-miR-208b-5p	81.0203	NM_173647

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Motifs and transcription factors (TFs) regulating RNF149

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF149	metacluster_7.13	ZFX (directAnnotation).
RNF149	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RNF149	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RNF149	taipale_tf_pairs__GCM1_FOXI1_RTMAACATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
RNF149	transfac_pro__M06484	ZNF683 (directAnnotation).
RNF149	transfac_pro__M06857	ZNF611 (directAnnotation).
RNF149	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
RNF149	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RNF149	metacluster_131.3	ZNF436 (inferredBy_Orthology).
RNF149	jaspar__MA0131.2	HINFP (directAnnotation).
RNF149	transfac_pro__M00652	NRF1 (directAnnotation).
RNF149	hdpi__NRL	NRL (directAnnotation).
RNF149	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RNF149	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RNF149	hdpi__HIP2	UBE2K (directAnnotation).
RNF149	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RNF149	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RNF149	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
RNF149	transfac_pro__M04646	FOXN4 (directAnnotation).
RNF149	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
RNF149	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RNF149	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RNF149	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
RNF149	transfac_public__M00040	ATF2 (directAnnotation).
RNF149	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
RNF149	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."