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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF144B

Summary for RNF144B

Gene information	Gene symbol	RNF144B
	Ensembl ID	ENSG00000137393
	Entrez ID	255488
	Gene name	ring finger protein 144B
	Synonyms	bA528A10.3\|IBRDC2\|P53RFP
	Gene type	protein_coding
	UniProtAcc	Q7Z419

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Dataset with differentially expressed gene: RNF144B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.309122	6.03e-44
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	-0.342304	2.91e-31
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.341169	0.00e+00

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Expression of RNF144B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF144B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF144B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF144B	hsa-miR-6809-5p	98.8567	NM_182757
RNF144B	hsa-miR-3148	98.1152	NM_182757
RNF144B	hsa-miR-15a-5p	96.5408	NM_182757
RNF144B	hsa-miR-15b-5p	96.5408	NM_182757
RNF144B	hsa-miR-195-5p	96.2867	NM_182757
RNF144B	hsa-miR-16-5p	96.2867	NM_182757
RNF144B	hsa-miR-424-5p	96.1997	NM_182757
RNF144B	hsa-miR-497-5p	96.1997	NM_182757
RNF144B	hsa-miR-6838-5p	96.1997	NM_182757
RNF144B	hsa-miR-8485	95.7055	NM_182757
RNF144B	hsa-miR-4524a-5p	94.3444	NM_182757
RNF144B	hsa-miR-4524b-5p	94.3444	NM_182757
RNF144B	hsa-miR-646	93.6338	NM_182757
RNF144B	hsa-miR-3612	93.3009	NM_182757
RNF144B	hsa-miR-650	93.3009	NM_182757
RNF144B	hsa-miR-503-5p	93.1461	NM_182757
RNF144B	hsa-miR-519d-5p	92.875	NM_182757
RNF144B	hsa-miR-607	92.5832	NM_182757
RNF144B	hsa-miR-3658	89.8463	NM_182757
RNF144B	hsa-miR-4286	88.7744	NM_182757
RNF144B	hsa-miR-3662	87.1307	NM_182757
RNF144B	hsa-miR-4727-5p	87.067	NM_182757
RNF144B	hsa-miR-490-3p	86.4325	NM_182757
RNF144B	hsa-miR-4695-5p	85.7747	NM_182757
RNF144B	hsa-miR-4482-3p	85.6555	NM_182757
RNF144B	hsa-miR-3941	85.1689	NM_182757
RNF144B	hsa-miR-3145-5p	84.8207	NM_182757
RNF144B	hsa-miR-3613-3p	84.1578	NM_182757
RNF144B	hsa-miR-144-5p	83.8033	NM_182757
RNF144B	hsa-miR-31-5p	83.623	NM_182757
RNF144B	hsa-miR-7111-3p	83.3868	NM_182757
RNF144B	hsa-miR-616-3p	82.6876	NM_182757
RNF144B	hsa-miR-3973	82.6296	NM_182757
RNF144B	hsa-miR-4474-3p	81.7586	NM_182757
RNF144B	hsa-miR-519e-5p	81.1797	NM_182757
RNF144B	hsa-miR-515-5p	81.1797	NM_182757
RNF144B	hsa-miR-4293	80.7509	NM_182757
RNF144B	hsa-miR-3646	80.2415	NM_182757
RNF144B	hsa-miR-5003-5p	80.0088	NM_182757

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Motifs and transcription factors (TFs) regulating RNF144B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF144B	transfac_pro__M05611	SALL3 (directAnnotation).
RNF144B	metacluster_188.1	FOXN2; FOXO4 (directAnnotation). FOXJ1; FOXO3 (inferredBy_Orthology).
RNF144B	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).
RNF144B	metacluster_155.11	SPZ1 (directAnnotation).
RNF144B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RNF144B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RNF144B	tfdimers__MD00167	HIC1; MAFA (directAnnotation).
RNF144B	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RNF144B	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
RNF144B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RNF144B	transfac_public__M00005	TFAP4 (directAnnotation).
RNF144B	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
RNF144B	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
RNF144B	transfac_pro__M06553	ZNF420 (directAnnotation).
RNF144B	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
RNF144B	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
RNF144B	tfdimers__MD00342	IRF1; YY1 (directAnnotation).
RNF144B	dbtfbs__NCOA3_MCF-7_ENCSR573OJP_merged_N2	NCOA3 (directAnnotation).
RNF144B	transfac_pro__M06485	ZNF808 (directAnnotation).
RNF144B	transfac_pro__M06531	ZNF555 (directAnnotation).
RNF144B	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
RNF144B	transfac_pro__M06737	ZNF226 (directAnnotation).
RNF144B	transfac_pro__M05896	ZNF713 (directAnnotation).
RNF144B	jaspar__MA1963.1	SATB1 (directAnnotation).
RNF144B	transfac_pro__M05743	ZNF57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."