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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF144A

Summary for RNF144A

Gene information	Gene symbol	RNF144A
	Ensembl ID	ENSG00000151692
	Entrez ID	9781
	Gene name	ring finger protein 144A
	Synonyms	hUIP4\|KIAA0161\|RNF144\|UBCE7IP4
	Gene type	protein_coding
	UniProtAcc	P50876

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Dataset with differentially expressed gene: RNF144A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of RNF144A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF144A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF144A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF144A	hsa-miR-6512-3p	97.3317	NM_014746
RNF144A	hsa-miR-6720-5p	97.3317	NM_014746
RNF144A	hsa-miR-548an	95.3536	NM_014746
RNF144A	hsa-miR-2392	94.2066	NM_014746
RNF144A	hsa-miR-300	94.1661	NM_014746
RNF144A	hsa-miR-381-3p	94.1661	NM_014746
RNF144A	hsa-miR-3928-5p	93.0771	NM_014746
RNF144A	hsa-miR-6806-3p	93.0771	NM_014746
RNF144A	hsa-miR-5011-5p	92.3423	NM_014746
RNF144A	hsa-miR-4698	91.1303	NM_014746
RNF144A	hsa-miR-216a-3p	89.8294	NM_014746
RNF144A	hsa-miR-128-3p	89.8294	NM_014746
RNF144A	hsa-miR-891a-3p	89.718	NM_014746
RNF144A	hsa-miR-4762-5p	88.9342	NM_014746
RNF144A	hsa-miR-6755-3p	88.5779	NM_014746
RNF144A	hsa-miR-6797-3p	88.3958	NM_014746
RNF144A	hsa-miR-499b-3p	87.6824	NM_014746
RNF144A	hsa-miR-499a-3p	87.6824	NM_014746
RNF144A	hsa-miR-3910	87.3343	NM_014746
RNF144A	hsa-miR-3681-3p	87.0064	NM_014746
RNF144A	hsa-miR-190a-3p	86.9846	NM_014746
RNF144A	hsa-miR-4775	86.1739	NM_014746
RNF144A	hsa-miR-2115-3p	85.4489	NM_014746
RNF144A	hsa-miR-3160-3p	85.3722	NM_014746
RNF144A	hsa-miR-6076	85.1292	NM_014746
RNF144A	hsa-miR-888-3p	84.4916	NM_014746
RNF144A	hsa-miR-338-3p	84.3145	NM_014746
RNF144A	hsa-miR-7851-3p	83.9866	NM_014746
RNF144A	hsa-miR-5003-5p	83.5612	NM_014746
RNF144A	hsa-miR-513a-5p	82.7141	NM_014746
RNF144A	hsa-miR-1258	82.5406	NM_014746
RNF144A	hsa-miR-541-5p	81.7439	NM_014746
RNF144A	hsa-miR-6827-3p	81.471	NM_014746
RNF144A	hsa-miR-7161-5p	80.9675	NM_014746
RNF144A	hsa-miR-4311	80.7479	NM_014746
RNF144A	hsa-miR-1290	80.5412	NM_014746
RNF144A	hsa-miR-7-5p	80.1192	NM_014746
RNF144A	hsa-miR-587	80.0572	NM_014746
RNF144A	hsa-miR-12124	80.0184	NM_014746

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Motifs and transcription factors (TFs) regulating RNF144A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF144A	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
RNF144A	transfac_pro__M01783	SP2 (directAnnotation).
RNF144A	transfac_pro__M06568	ZNF501 (directAnnotation).
RNF144A	transfac_pro__M06487	ZNF695 (directAnnotation).
RNF144A	transfac_pro__M06279	ZNF124 (directAnnotation).
RNF144A	transfac_pro__M06837	ZNF367 (directAnnotation).
RNF144A	transfac_pro__M06451	ZNF614 (directAnnotation).
RNF144A	taipale_tf_pairs__ETV2_ONECUT2_RCCGGAANNNNNNRATCRATN_CAP_repr	ETV2; ONECUT2 (directAnnotation).
RNF144A	transfac_public__M00291	FOXC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."