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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF141

Summary for RNF141

Gene information	Gene symbol	RNF141
	Ensembl ID	ENSG00000110315
	Entrez ID	50862
	Gene name	ring finger protein 141
	Synonyms	ZFP26\|ZNF230
	Gene type	protein_coding
	UniProtAcc	Q8WVD5

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Dataset with differentially expressed gene: RNF141

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.513332	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.283849	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.407047	0.00e+00

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Expression of RNF141 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF141

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF141

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF141	hsa-miR-548p	99.7495	NM_016422
RNF141	hsa-miR-7-5p	96.0054	NM_016422
RNF141	hsa-miR-561-3p	94.9496	NM_016422
RNF141	hsa-miR-651-3p	93.9029	NM_016422
RNF141	hsa-miR-5692a	93.5555	NM_016422
RNF141	hsa-miR-1297	93.241	NM_016422
RNF141	hsa-miR-3163	93.1889	NM_016422
RNF141	hsa-miR-4530	92.3174	NM_016422
RNF141	hsa-miR-6077	92.2129	NM_016422
RNF141	hsa-miR-9985	91.6421	NM_016422
RNF141	hsa-miR-27b-3p	91.6421	NM_016422
RNF141	hsa-miR-27a-3p	91.6421	NM_016422
RNF141	hsa-miR-5011-5p	91.4227	NM_016422
RNF141	hsa-miR-6083	90.8499	NM_016422
RNF141	hsa-miR-92a-3p	90.6209	NM_016422
RNF141	hsa-miR-92b-3p	90.6209	NM_016422
RNF141	hsa-miR-32-5p	90.6209	NM_016422
RNF141	hsa-miR-26a-5p	90.135	NM_016422
RNF141	hsa-miR-26b-5p	90.135	NM_016422
RNF141	hsa-miR-6805-5p	89.5159	NM_016422
RNF141	hsa-miR-6515-3p	89.129	NM_016422
RNF141	hsa-miR-367-3p	89.0608	NM_016422
RNF141	hsa-miR-25-3p	89.0608	NM_016422
RNF141	hsa-miR-363-3p	89.0608	NM_016422
RNF141	hsa-miR-4465	88.4954	NM_016422
RNF141	hsa-miR-4521	87.6144	NM_016422
RNF141	hsa-miR-891b	86.9261	NM_016422
RNF141	hsa-miR-629-3p	86.6589	NM_016422
RNF141	hsa-miR-32-3p	86.2833	NM_016422
RNF141	hsa-miR-548at-5p	86.2421	NM_016422
RNF141	hsa-miR-371a-5p	86.0206	NM_016422
RNF141	hsa-miR-203a-3p	85.6735	NM_016422
RNF141	hsa-miR-30a-3p	83.1365	NM_016422
RNF141	hsa-miR-30d-3p	83.1365	NM_016422
RNF141	hsa-miR-30e-3p	83.1365	NM_016422
RNF141	hsa-miR-5187-3p	83.1144	NM_016422
RNF141	hsa-miR-383-5p	82.1184	NM_016422
RNF141	hsa-miR-936	80.9626	NM_016422
RNF141	hsa-miR-590-3p	80.1624	NM_016422

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Motifs and transcription factors (TFs) regulating RNF141

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF141	hdpi__ETV4	ETV4 (directAnnotation).
RNF141	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RNF141	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
RNF141	transfac_pro__M06156	ZNF75D (directAnnotation).
RNF141	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
RNF141	hdpi__TP73	TP73 (directAnnotation).
RNF141	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
RNF141	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
RNF141	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RNF141	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RNF141	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RNF141	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RNF141	jaspar__MA1122.1	TFDP1 (directAnnotation).
RNF141	metacluster_135.11	NR2C2 (directAnnotation).
RNF141	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RNF141	tfdimers__MD00038	TFAP2C (directAnnotation).
RNF141	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RNF141	metacluster_7.13	ZFX (directAnnotation).
RNF141	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RNF141	cisbp__M00968	MTF2 (directAnnotation).
RNF141	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RNF141	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RNF141	cisbp__M00341	PAX6 (directAnnotation).
RNF141	metacluster_198.3	ZFP64 (directAnnotation).
RNF141	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RNF141	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RNF141	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RNF141	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RNF141	cisbp__M00788	ZFY (inferredBy_Orthology).
RNF141	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RNF141	metacluster_175.1	ZNF283 (directAnnotation).
RNF141	hdpi__ZNF304	ZNF304 (directAnnotation).
RNF141	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RNF141	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RNF141	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RNF141	transfac_pro__M01199	TRIM28 (directAnnotation).
RNF141	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RNF141	metacluster_151.2	ZNF23 (directAnnotation).
RNF141	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RNF141	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RNF141	transfac_pro__M03806	ZBTB7C (directAnnotation).
RNF141	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."