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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF11

Summary for RNF11

Gene information	Gene symbol	RNF11
	Ensembl ID	ENSG00000123091
	Entrez ID	26994
	Gene name	ring finger protein 11
	Synonyms	CGI-123\|MGC51169\|Sid1669p
	Gene type	protein_coding
	UniProtAcc	Q9Y3C5

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Dataset with differentially expressed gene: RNF11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.250073	5.16e-08
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.339282	1.43e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.431198	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.260125	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.488106	0.00e+00

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Expression of RNF11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF11	hsa-miR-19a-3p	98.7993	NM_014372
RNF11	hsa-miR-19b-3p	98.7993	NM_014372
RNF11	hsa-miR-4503	98.4575	NM_014372
RNF11	hsa-miR-3163	97.2318	NM_014372
RNF11	hsa-miR-4283	96.3795	NM_014372
RNF11	hsa-miR-4801	93.5827	NM_014372
RNF11	hsa-miR-297	93.5812	NM_014372
RNF11	hsa-miR-4731-3p	93.3289	NM_014372
RNF11	hsa-miR-8485	91.7618	NM_014372
RNF11	hsa-miR-196a-1-3p	91.686	NM_014372
RNF11	hsa-miR-202-5p	91.4689	NM_014372
RNF11	hsa-miR-2115-3p	91.2655	NM_014372
RNF11	hsa-miR-651-3p	91.1535	NM_014372
RNF11	hsa-miR-302c-5p	90.8737	NM_014372
RNF11	hsa-miR-519e-3p	90.668	NM_014372
RNF11	hsa-miR-515-3p	90.668	NM_014372
RNF11	hsa-miR-33b-3p	90.668	NM_014372
RNF11	hsa-miR-4437	90.42	NM_014372
RNF11	hsa-miR-5696	89.7632	NM_014372
RNF11	hsa-miR-5190	89.7204	NM_014372
RNF11	hsa-miR-5692a	89.6584	NM_014372
RNF11	hsa-miR-10400-3p	89.6201	NM_014372
RNF11	hsa-miR-4674	89.6201	NM_014372
RNF11	hsa-miR-580-3p	89.1724	NM_014372
RNF11	hsa-miR-498-5p	88.9112	NM_014372
RNF11	hsa-miR-6508-5p	88.821	NM_014372
RNF11	hsa-miR-3148	88.8028	NM_014372
RNF11	hsa-miR-3149	88.3201	NM_014372
RNF11	hsa-miR-8067	87.8019	NM_014372
RNF11	hsa-miR-1184	87.757	NM_014372
RNF11	hsa-miR-192-3p	87.664	NM_014372
RNF11	hsa-miR-8069	87.4411	NM_014372
RNF11	hsa-miR-208b-5p	86.4248	NM_014372
RNF11	hsa-miR-208a-5p	86.4248	NM_014372
RNF11	hsa-miR-3143	86.2605	NM_014372
RNF11	hsa-miR-4799-5p	86.1175	NM_014372
RNF11	hsa-miR-642b-3p	85.7755	NM_014372
RNF11	hsa-miR-642a-3p	85.7755	NM_014372
RNF11	hsa-miR-551b-5p	85.6395	NM_014372
RNF11	hsa-miR-3922-5p	85.191	NM_014372
RNF11	hsa-miR-12129	84.9439	NM_014372
RNF11	hsa-miR-199a-5p	83.1847	NM_014372
RNF11	hsa-miR-199b-5p	83.1847	NM_014372
RNF11	hsa-miR-5580-3p	82.3265	NM_014372
RNF11	hsa-miR-361-5p	81.2576	NM_014372
RNF11	hsa-miR-203a-5p	80.912	NM_014372
RNF11	hsa-miR-92a-3p	80.5469	NM_014372
RNF11	hsa-miR-92b-3p	80.5469	NM_014372
RNF11	hsa-miR-32-5p	80.5469	NM_014372
RNF11	hsa-miR-153-5p	80.0723	NM_014372

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Motifs and transcription factors (TFs) regulating RNF11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF11	metacluster_7.13	ZFX (directAnnotation).
RNF11	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RNF11	transfac_pro__M05479	ZNF580 (directAnnotation).
RNF11	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RNF11	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RNF11	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RNF11	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RNF11	jaspar__MA0079.5	SP1 (directAnnotation).
RNF11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RNF11	transfac_pro__M01253	CNOT3 (directAnnotation).
RNF11	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
RNF11	cisbp__M00968	MTF2 (directAnnotation).
RNF11	transfac_pro__M04817	ZBTB33 (directAnnotation).
RNF11	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RNF11	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RNF11	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RNF11	jaspar__MA0748.2	YY2 (directAnnotation).
RNF11	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RNF11	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RNF11	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RNF11	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RNF11	jaspar__MA1721.1	ZNF93 (directAnnotation).
RNF11	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RNF11	transfac_pro__M01199	TRIM28 (directAnnotation).
RNF11	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RNF11	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RNF11	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RNF11	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RNF11	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
RNF11	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RNF11	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RNF11	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RNF11	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RNF11	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RNF11	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RNF11	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
RNF11	transfac_pro__M07310	SP5 (directAnnotation).
RNF11	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RNF11	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RNF11	transfac_pro__M00938	E2F1 (directAnnotation).
RNF11	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RNF11	metacluster_175.1	ZNF283 (directAnnotation).
RNF11	tfdimers__MD00364	WT1 (directAnnotation).
RNF11	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RNF11	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RNF11	transfac_pro__M04916	TAF1 (directAnnotation).
RNF11	transfac_pro__M01303	SP1 (directAnnotation).
RNF11	metacluster_143.13	ZBTB7A (directAnnotation).
RNF11	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
RNF11	transfac_pro__M00514	ATF4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."