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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF103

Summary for RNF103

Gene information	Gene symbol	RNF103
	Ensembl ID	ENSG00000239305
	Entrez ID	7844
	Gene name	ring finger protein 103
	Synonyms	hkf-1\|KF1\|ZFP103
	Gene type	protein_coding
	UniProtAcc	O00237

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Dataset with differentially expressed gene: RNF103

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.319887	1.04e-26

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Expression of RNF103 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF103

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF103

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF103	hsa-miR-376c-3p	96.1992	NM_001198952
RNF103	hsa-miR-6831-3p	95.6999	NM_001198951
RNF103	hsa-miR-548as-3p	94.2569	NM_001198952
RNF103	hsa-miR-218-5p	93.9958	NM_001198951
RNF103	hsa-miR-1258	91.5838	NM_001198952
RNF103	hsa-miR-4793-3p	89.3758	NM_001198951
RNF103	hsa-miR-508-3p	88.7468	NM_001198951
RNF103	hsa-miR-513c-3p	88.3958	NM_001198951
RNF103	hsa-miR-513a-3p	88.3958	NM_001198951
RNF103	hsa-miR-590-5p	87.8403	NM_001198951
RNF103	hsa-miR-21-5p	87.8403	NM_001198951
RNF103	hsa-miR-6715b-3p	87.7526	NM_001198951
RNF103	hsa-miR-29b-1-5p	87.4071	NM_001198951
RNF103	hsa-miR-6715a-3p	86.4719	NM_001198951
RNF103	hsa-miR-6822-5p	86.2362	NM_001198952
RNF103	hsa-miR-6750-5p	86.2362	NM_001198952
RNF103	hsa-miR-215-3p	86.0245	NM_001198951
RNF103	hsa-miR-888-5p	85.1003	NM_001198951
RNF103	hsa-miR-2113	83.7378	NM_001198951
RNF103	hsa-miR-3606-3p	82.8456	NM_001198951
RNF103	hsa-miR-4775	82.6845	NM_001198952
RNF103	hsa-miR-3143	82.5494	NM_001198951
RNF103	hsa-miR-586	82.5175	NM_001198951
RNF103	hsa-miR-1306-5p	81.9714	NM_001198952
RNF103	hsa-miR-552-5p	81.4237	NM_001198951
RNF103	hsa-miR-7106-5p	80.8662	NM_001198951
RNF103	hsa-miR-548an	80.7206	NM_001198951
RNF103	hsa-miR-3118	80.7202	NM_001198951
RNF103	hsa-miR-6820-3p	80.7202	NM_001198951
RNF103	hsa-miR-3164	80.7202	NM_001198951
RNF103	hsa-miR-134-5p	80.7202	NM_001198951
RNF103	hsa-miR-323b-3p	80.5213	NM_001198952
RNF103	hsa-miR-5692a	80.4718	NM_001198951
RNF103	hsa-miR-4739	80.1731	NM_001198951
RNF103	hsa-miR-1321	80.1731	NM_001198951
RNF103	hsa-miR-4756-5p	80.1731	NM_001198951

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Motifs and transcription factors (TFs) regulating RNF103

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF103	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."