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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: RMND5A

Summary for RMND5A

Gene informationGene symbol

RMND5A

Ensembl ID

ENSG00000153561

Entrez ID

64795

Gene namerequired for meiotic nuclear division 5 homolog A
SynonymsFLJ13910|GID2|GID2A|p44CTLH|RMD5
Gene typeprotein_coding
UniProtAcc

Q9H871


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Dataset with differentially expressed gene: RMND5A

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.6862013.45e-03

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Expression of RMND5A in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RMND5A

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RMND5A

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RMND5Ahsa-miR-548e-5p99.617NM_022780
RMND5Ahsa-miR-10527-5p99.4742NM_022780
RMND5Ahsa-miR-569699.0611NM_022780
RMND5Ahsa-miR-455-3p98.9413NM_022780
RMND5Ahsa-miR-442298.9127NM_022780
RMND5Ahsa-miR-548p98.7212NM_022780
RMND5Ahsa-miR-55998.5618NM_022780
RMND5Ahsa-miR-548ap-5p98.2918NM_022780
RMND5Ahsa-miR-548as-5p98.2918NM_022780
RMND5Ahsa-miR-548ae-5p98.2918NM_022780
RMND5Ahsa-miR-548a-5p98.2918NM_022780
RMND5Ahsa-miR-548h-5p98.2918NM_022780
RMND5Ahsa-miR-548ay-5p98.2918NM_022780
RMND5Ahsa-miR-548j-5p98.2918NM_022780
RMND5Ahsa-miR-548bb-5p98.2918NM_022780
RMND5Ahsa-miR-548am-5p98.2918NM_022780
RMND5Ahsa-miR-548aq-5p98.2918NM_022780
RMND5Ahsa-miR-548ab98.2918NM_022780
RMND5Ahsa-miR-548y98.2918NM_022780
RMND5Ahsa-miR-548w98.2918NM_022780
RMND5Ahsa-miR-548c-5p98.2918NM_022780
RMND5Ahsa-miR-548ak98.2918NM_022780
RMND5Ahsa-miR-548i98.2918NM_022780
RMND5Ahsa-miR-548ad-5p98.2918NM_022780
RMND5Ahsa-miR-548b-5p98.2918NM_022780
RMND5Ahsa-miR-548o-5p98.2918NM_022780
RMND5Ahsa-miR-548d-5p98.2918NM_022780
RMND5Ahsa-miR-548au-5p98.2918NM_022780
RMND5Ahsa-miR-548ar-5p98.2918NM_022780
RMND5Ahsa-miR-138-5p98.1733NM_022780
RMND5Ahsa-miR-392497.6265NM_022780
RMND5Ahsa-miR-148b-3p97.2638NM_022780
RMND5Ahsa-miR-152-3p97.2638NM_022780
RMND5Ahsa-miR-148a-3p97.2638NM_022780
RMND5Ahsa-miR-5002-5p97.0997NM_022780
RMND5Ahsa-miR-9-5p96.6957NM_022780
RMND5Ahsa-miR-848596.49NM_022780
RMND5Ahsa-miR-394196.0267NM_022780
RMND5Ahsa-miR-58795.9331NM_022780
RMND5Ahsa-miR-670-5p95.8128NM_022780
RMND5Ahsa-miR-1250-3p95.521NM_022780
RMND5Ahsa-miR-134-5p95.4056NM_022780
RMND5Ahsa-miR-311895.4056NM_022780
RMND5Ahsa-miR-472995.1512NM_022780
RMND5Ahsa-miR-10b-3p95.0961NM_022780
RMND5Ahsa-miR-345-3p94.4953NM_022780
RMND5Ahsa-miR-998594.4385NM_022780
RMND5Ahsa-miR-27b-3p94.4385NM_022780
RMND5Ahsa-miR-27a-3p94.4385NM_022780
RMND5Ahsa-miR-6828-3p94.0939NM_022780
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Motifs and transcription factors (TFs) regulating RMND5A

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RMND5Akznf__ZNF594_Schmitges2016_RCADEZNF594 (directAnnotation).
RMND5Ametacluster_195.2EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RMND5Akznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
RMND5Atransfac_pro__M04617ZBTB7A (directAnnotation).
RMND5Ametacluster_3.5KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RMND5Ataipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
RMND5Ataipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
RMND5Atransfac_pro__M07387ZBTB7A (directAnnotation).
RMND5Atransfac_pro__M07436WT1 (directAnnotation).
RMND5Atransfac_pro__M07461KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RMND5Atransfac_pro__M00716ZBTB14 (directAnnotation).
RMND5Aswissregulon__hs__CHD1CHD1 (directAnnotation).
RMND5Ahdpi__HIP2UBE2K (directAnnotation).
RMND5Ataipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_reprGCM1; SPDEF (directAnnotation).
RMND5Ametacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RMND5Atransfac_pro__M04893TAF1 (directAnnotation).
RMND5Atransfac_pro__M03876ZBTB33 (directAnnotation).
RMND5Ametacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RMND5Ametacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RMND5Akznf__ZNF441_Imbeault2017_RP_RCADEZNF441 (directAnnotation).
RMND5Atransfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RMND5Ametacluster_3.7SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."