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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RIT1

Summary for RIT1

Gene information	Gene symbol	RIT1
	Ensembl ID	ENSG00000143622
	Entrez ID	6016
	Gene name	Ras like without CAAX 1
	Synonyms	MGC125864\|MGC125865\|RIBB\|RIT\|ROC1
	Gene type	protein_coding
	UniProtAcc	Q92963

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Dataset with differentially expressed gene: RIT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.255313	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.260338	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.68009	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.275325	8.77e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.365261	2.97e-27

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Expression of RIT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RIT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RIT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RIT1	hsa-miR-5011-5p	99.9958	NM_001256821
RIT1	hsa-miR-190a-3p	99.884	NM_001256821
RIT1	hsa-miR-6732-3p	96.0228	NM_001256821
RIT1	hsa-miR-4504	94.29	NM_001256821
RIT1	hsa-miR-345-3p	93.8602	NM_001256820
RIT1	hsa-miR-320d	92.5173	NM_001256820
RIT1	hsa-miR-320a-3p	92.5173	NM_001256820
RIT1	hsa-miR-320c	92.5173	NM_001256820
RIT1	hsa-miR-320b	92.5173	NM_001256820
RIT1	hsa-miR-4429	92.5173	NM_001256820
RIT1	hsa-miR-8066	90.8387	NM_001256821
RIT1	hsa-miR-3117-5p	90.5201	NM_001256821
RIT1	hsa-miR-425-5p	90.1513	NM_001256821
RIT1	hsa-miR-4501	89.5719	NM_001256821
RIT1	hsa-miR-3688-3p	89.0723	NM_001256821
RIT1	hsa-miR-217-3p	88.9445	NM_001256820
RIT1	hsa-miR-6840-3p	87.0275	NM_001256821
RIT1	hsa-miR-6742-3p	84.5312	NM_001256821
RIT1	hsa-miR-6780a-5p	83.7867	NM_001256821
RIT1	hsa-miR-330-5p	83.3522	NM_001256821
RIT1	hsa-miR-9-3p	83.3065	NM_001256820
RIT1	hsa-miR-6828-5p	83.241	NM_001256820
RIT1	hsa-miR-5094	82.4394	NM_001256820
RIT1	hsa-miR-1277-5p	81.0225	NM_001256821
RIT1	hsa-miR-6809-3p	80.7421	NM_001256821

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Motifs and transcription factors (TFs) regulating RIT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RIT1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RIT1	jaspar__MA0079.5	SP1 (directAnnotation).
RIT1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RIT1	transfac_public__M00491	PATZ1 (directAnnotation).
RIT1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RIT1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RIT1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RIT1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RIT1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."