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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RIF1

Summary for RIF1

Gene information	Gene symbol	RIF1
	Ensembl ID	ENSG00000080345
	Entrez ID	55183
	Gene name	replication timing regulatory factor 1
	Synonyms	FLJ10599\|FLJ12870
	Gene type	protein_coding
	UniProtAcc	Q5UIP0

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Dataset with differentially expressed gene: RIF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.318927	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.270728	2.86e-10
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.405622	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.436724	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.336123	2.78e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.256319	1.19e-30

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Expression of RIF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RIF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RIF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RIF1	hsa-miR-33a-3p	95.9406	NM_001177665
RIF1	hsa-miR-1272	95.9005	NM_001177665
RIF1	hsa-miR-4797-3p	95.6283	NM_001177665
RIF1	hsa-miR-607	94.3606	NM_001177665
RIF1	hsa-miR-4276	94.2647	NM_001177665
RIF1	hsa-miR-1284	94.0476	NM_001177663
RIF1	hsa-miR-4482-3p	93.7222	NM_001177665
RIF1	hsa-miR-218-5p	93.6877	NM_001177665
RIF1	hsa-miR-4477b	92.8874	NM_001177665
RIF1	hsa-miR-3163	92.0835	NM_001177665
RIF1	hsa-miR-6885-3p	91.5059	NM_001177665
RIF1	hsa-miR-30a-3p	90.8391	NM_001177663
RIF1	hsa-miR-30e-3p	90.8391	NM_001177663
RIF1	hsa-miR-30d-3p	90.8391	NM_001177663
RIF1	hsa-miR-3671	90.6449	NM_001177665
RIF1	hsa-miR-520d-5p	90.4014	NM_001177663
RIF1	hsa-miR-524-5p	90.4014	NM_001177663
RIF1	hsa-miR-548ac	89.5227	NM_001177665
RIF1	hsa-miR-548h-3p	89.5227	NM_001177665
RIF1	hsa-miR-548z	89.5227	NM_001177665
RIF1	hsa-miR-1277-5p	89.2494	NM_001177663
RIF1	hsa-miR-6719-3p	88.8905	NM_001177665
RIF1	hsa-miR-450a-1-3p	88.3882	NM_001177665
RIF1	hsa-miR-1250-3p	87.7252	NM_001177663
RIF1	hsa-miR-548d-3p	87.2515	NM_001177665
RIF1	hsa-miR-506-3p	87.0277	NM_001177665
RIF1	hsa-miR-124-3p	87.0277	NM_001177665
RIF1	hsa-miR-3646	86.6489	NM_001177665
RIF1	hsa-miR-548bb-3p	86.2082	NM_001177665
RIF1	hsa-miR-4264	86.1059	NM_001177665
RIF1	hsa-miR-6507-5p	84.1847	NM_001177663
RIF1	hsa-miR-552-5p	83.8238	NM_001177665
RIF1	hsa-miR-545-3p	83.707	NM_001177665
RIF1	hsa-miR-579-3p	83.2893	NM_001177665
RIF1	hsa-miR-664b-3p	83.2893	NM_001177665
RIF1	hsa-miR-7856-5p	82.9729	NM_001177665
RIF1	hsa-miR-98-3p	82.9075	NM_001177663
RIF1	hsa-let-7f-1-3p	82.9075	NM_001177663
RIF1	hsa-let-7b-3p	82.9075	NM_001177663
RIF1	hsa-let-7a-3p	82.9075	NM_001177663
RIF1	hsa-miR-651-3p	81.5253	NM_001177665
RIF1	hsa-miR-15b-5p	81.0804	NM_001177663
RIF1	hsa-miR-195-5p	81.0804	NM_001177663
RIF1	hsa-miR-15a-5p	81.0804	NM_001177663
RIF1	hsa-miR-16-5p	81.0804	NM_001177663
RIF1	hsa-miR-503-5p	81.0804	NM_001177663
RIF1	hsa-miR-510-3p	80.8583	NM_001177663
RIF1	hsa-miR-7-1-3p	80.3959	NM_001177665
RIF1	hsa-miR-7-2-3p	80.3959	NM_001177665

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Motifs and transcription factors (TFs) regulating RIF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RIF1	metacluster_7.13	ZFX (directAnnotation).
RIF1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RIF1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RIF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RIF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RIF1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RIF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RIF1	hdpi__ETV4	ETV4 (directAnnotation).
RIF1	transfac_pro__M06071	ZNF814 (directAnnotation).
RIF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RIF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RIF1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
RIF1	transfac_pro__M04826	EP300 (directAnnotation).
RIF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RIF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RIF1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RIF1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
RIF1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RIF1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RIF1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RIF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RIF1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RIF1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RIF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RIF1	transfac_pro__M02090	E2F4 (directAnnotation).
RIF1	transfac_pro__M01714	KLF15 (directAnnotation).
RIF1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RIF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
RIF1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
RIF1	transfac_pro__M02089	E2F3 (directAnnotation).
RIF1	metacluster_3.14	WT1; WT1 (directAnnotation).
RIF1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RIF1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RIF1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RIF1	cisbp__M07938	E2F1 (directAnnotation).
RIF1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RIF1	transfac_pro__M07436	WT1 (directAnnotation).
RIF1	transfac_pro__M02281	SP1 (directAnnotation).
RIF1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RIF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RIF1	transfac_pro__M02898	SMAD3 (directAnnotation).
RIF1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RIF1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
RIF1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RIF1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RIF1	transfac_pro__M04748	GABPA (directAnnotation).
RIF1	hdpi__TP73	TP73 (directAnnotation).
RIF1	transfac_public__M00024	E2F1 (directAnnotation).
RIF1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RIF1	swissregulon__hs__ETV6	ETV6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."