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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RHPN2

Summary for RHPN2

Gene information	Gene symbol	RHPN2
	Ensembl ID	ENSG00000131941
	Entrez ID	85415
	Gene name	rhophilin Rho GTPase binding protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8IUC4

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Dataset with differentially expressed gene: RHPN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.414947	3.64e-44

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Expression of RHPN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RHPN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RHPN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RHPN2	hsa-miR-3646	96.0475	NM_033103
RHPN2	hsa-miR-92b-3p	95.7899	NM_033103
RHPN2	hsa-miR-92a-3p	95.7899	NM_033103
RHPN2	hsa-miR-32-5p	95.7899	NM_033103
RHPN2	hsa-miR-363-3p	95.4379	NM_033103
RHPN2	hsa-miR-367-3p	95.4379	NM_033103
RHPN2	hsa-miR-25-3p	95.4379	NM_033103
RHPN2	hsa-miR-1179	92.0894	NM_033103
RHPN2	hsa-miR-516a-3p	91.829	NM_033103
RHPN2	hsa-miR-516b-3p	91.829	NM_033103
RHPN2	hsa-miR-7162-5p	91.829	NM_033103
RHPN2	hsa-miR-183-5p	90.6603	NM_033103
RHPN2	hsa-miR-548n	89.9137	NM_033103
RHPN2	hsa-miR-3152-3p	89.2392	NM_033103
RHPN2	hsa-miR-592	88.0814	NM_033103
RHPN2	hsa-miR-371a-5p	86.959	NM_033103
RHPN2	hsa-miR-411-3p	86.7785	NM_033103
RHPN2	hsa-miR-379-3p	86.7785	NM_033103
RHPN2	hsa-miR-451b	86.2507	NM_033103
RHPN2	hsa-miR-3117-5p	85.8771	NM_033103
RHPN2	hsa-miR-496	84.8089	NM_033103
RHPN2	hsa-miR-371b-5p	84.7911	NM_033103
RHPN2	hsa-miR-616-5p	84.7911	NM_033103
RHPN2	hsa-miR-373-5p	84.7911	NM_033103
RHPN2	hsa-miR-96-5p	84.6653	NM_033103
RHPN2	hsa-miR-12136	84.6018	NM_033103
RHPN2	hsa-miR-892a	84.5331	NM_033103
RHPN2	hsa-miR-2052	84.4394	NM_033103
RHPN2	hsa-miR-3913-5p	84.0263	NM_033103
RHPN2	hsa-miR-205-5p	83.6086	NM_033103
RHPN2	hsa-miR-5692a	83.3209	NM_033103
RHPN2	hsa-miR-548ab	83.0429	NM_033103
RHPN2	hsa-miR-548am-5p	83.0429	NM_033103
RHPN2	hsa-miR-548y	83.0429	NM_033103
RHPN2	hsa-miR-548b-5p	83.0429	NM_033103
RHPN2	hsa-miR-548a-5p	83.0429	NM_033103
RHPN2	hsa-miR-548ay-5p	83.0429	NM_033103
RHPN2	hsa-miR-548as-5p	83.0429	NM_033103
RHPN2	hsa-miR-559	83.0429	NM_033103
RHPN2	hsa-miR-548ad-5p	83.0429	NM_033103
RHPN2	hsa-miR-548ae-5p	83.0429	NM_033103
RHPN2	hsa-miR-548d-5p	83.0429	NM_033103
RHPN2	hsa-miR-548i	83.0429	NM_033103
RHPN2	hsa-miR-548bb-5p	83.0429	NM_033103
RHPN2	hsa-miR-548au-5p	83.0429	NM_033103
RHPN2	hsa-miR-548ak	83.0429	NM_033103
RHPN2	hsa-miR-548aq-5p	83.0429	NM_033103
RHPN2	hsa-miR-548h-5p	83.0429	NM_033103
RHPN2	hsa-miR-548w	83.0429	NM_033103
RHPN2	hsa-miR-548j-5p	83.0429	NM_033103

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Motifs and transcription factors (TFs) regulating RHPN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RHPN2	cisbp__M00341	PAX6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."