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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: RHAG

Summary for RHAG

Gene informationGene symbol

RHAG

Ensembl ID

ENSG00000112077

Entrez ID

6005

Gene nameRh associated glycoprotein
SynonymsCD241|RH50A|SLC42A1
Gene typeprotein_coding
UniProtAcc

Q02094


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Dataset with differentially expressed gene: RHAG

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAErythrocytes-0.7000061.82e-44

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreErythrocytes0.7545242.00e-39

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Expression of RHAG in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RHAG

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RHAG

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RHAGhsa-miR-3913-5p94.9591NM_000324
RHAGhsa-miR-6507-5p93.7526NM_000324
RHAGhsa-miR-312290.9504NM_000324
RHAGhsa-miR-4782-5p90.8437NM_000324
RHAGhsa-miR-570690.8437NM_000324
RHAGhsa-miR-548g-5p89.9823NM_000324
RHAGhsa-miR-548aj-5p89.9823NM_000324
RHAGhsa-miR-548f-5p89.9823NM_000324
RHAGhsa-miR-548x-5p89.9823NM_000324
RHAGhsa-miR-94489.1761NM_000324
RHAGhsa-miR-491-3p88.5997NM_000324
RHAGhsa-miR-432888.2759NM_000324
RHAGhsa-miR-1468-3p87.8572NM_000324
RHAGhsa-miR-548aw85.8988NM_000324
RHAGhsa-miR-708-3p82.8999NM_000324
RHAGhsa-miR-3664-5p82.7366NM_000324
RHAGhsa-miR-361882.5393NM_000324
RHAGhsa-miR-808082.318NM_000324
RHAGhsa-miR-6890-3p82.0935NM_000324
RHAGhsa-miR-6513-5p80.2439NM_000324
Page: 1

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Motifs and transcription factors (TFs) regulating RHAG

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RHAGtransfac_pro__M06340ZNF790 (directAnnotation).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."