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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RGS4

Summary for RGS4

Gene information	Gene symbol	RGS4
	Ensembl ID	ENSG00000117152
	Entrez ID	5999
	Gene name	regulator of G protein signaling 4
	Synonyms	SCZD9
	Gene type	protein_coding
	UniProtAcc	P49798

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Dataset with differentially expressed gene: RGS4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.89757	0.00e+00

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Expression of RGS4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RGS4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RGS4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RGS4	hsa-miR-6867-5p	100	NM_001113380
RGS4	hsa-miR-3663-3p	99.8449	NM_001113381
RGS4	hsa-miR-603	96.1421	NM_001113381
RGS4	hsa-miR-5007-5p	95.9369	NM_001113381
RGS4	hsa-miR-5011-5p	95.7696	NM_001113380
RGS4	hsa-miR-5692a	94.4567	NM_001113381
RGS4	hsa-miR-1253	93.9597	NM_001113380
RGS4	hsa-miR-342-3p	93.5562	NM_001113380
RGS4	hsa-miR-1297	93.2082	NM_001113381
RGS4	hsa-miR-340-5p	92.7736	NM_001113380
RGS4	hsa-miR-26a-5p	91.846	NM_001113381
RGS4	hsa-miR-26b-5p	91.846	NM_001113381
RGS4	hsa-let-7f-2-3p	91.4911	NM_001113380
RGS4	hsa-miR-1185-1-3p	91.4911	NM_001113380
RGS4	hsa-miR-1185-2-3p	91.4911	NM_001113380
RGS4	hsa-miR-374a-5p	91.3023	NM_001113380
RGS4	hsa-miR-5692b	90.3289	NM_001113380
RGS4	hsa-miR-5692c	90.3289	NM_001113380
RGS4	hsa-miR-374b-5p	90.0725	NM_001113380
RGS4	hsa-miR-942-3p	90.0413	NM_001113380
RGS4	hsa-miR-874-3p	89.793	NM_001113380
RGS4	hsa-miR-4491	89.5597	NM_001113380
RGS4	hsa-miR-4465	89.0207	NM_001113381
RGS4	hsa-miR-374c-5p	87.8913	NM_001113380
RGS4	hsa-miR-655-3p	87.8913	NM_001113380
RGS4	hsa-miR-4666b	87.7905	NM_001113380
RGS4	hsa-miR-4803	87.602	NM_001113380
RGS4	hsa-miR-3664-3p	87.0176	NM_001113381
RGS4	hsa-miR-7111-3p	86.6513	NM_001113380
RGS4	hsa-miR-6828-5p	85.5113	NM_001113381
RGS4	hsa-miR-466	85.3309	NM_001113380
RGS4	hsa-miR-6878-3p	85.1466	NM_001113380
RGS4	hsa-miR-548au-3p	84.9739	NM_001113380
RGS4	hsa-miR-4423-3p	84.2875	NM_001113381
RGS4	hsa-miR-498-5p	83.3101	NM_001113381
RGS4	hsa-miR-5684	83.2488	NM_001113380
RGS4	hsa-miR-4657	82.9957	NM_001113380
RGS4	hsa-miR-126-5p	82.809	NM_001113380
RGS4	hsa-miR-1305	82.4945	NM_001113381
RGS4	hsa-miR-7156-3p	82.4233	NM_001113380
RGS4	hsa-miR-548ar-3p	82.2122	NM_001113380
RGS4	hsa-miR-3180-5p	82.1705	NM_001113380
RGS4	hsa-miR-6758-3p	82.1557	NM_001113381
RGS4	hsa-miR-3163	81.733	NM_001113380
RGS4	hsa-miR-548x-5p	81.1823	NM_001113380
RGS4	hsa-miR-548g-5p	81.1823	NM_001113380
RGS4	hsa-miR-548f-5p	81.1823	NM_001113380
RGS4	hsa-miR-548aj-5p	81.1823	NM_001113380

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Motifs and transcription factors (TFs) regulating RGS4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."