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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RFK

Summary for RFK

Gene information	Gene symbol	RFK
	Ensembl ID	ENSG00000135002
	Entrez ID	55312
	Gene name	riboflavin kinase
	Synonyms	FLJ11149\|RIFK
	Gene type	protein_coding
	UniProtAcc	Q969G6

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Dataset with differentially expressed gene: RFK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.269342	4.91e-11
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.388498	1.35e-19
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.270795	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.351982	3.61e-24
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.425805	2.82e-22
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.332011	6.03e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.396838	7.49e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.288617	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.909482	0.00e+00

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Expression of RFK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RFK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RFK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RFK	hsa-miR-3922-5p	97.8605	NM_018339
RFK	hsa-miR-27a-5p	96.7547	NM_018339
RFK	hsa-miR-369-3p	94.8214	NM_018339
RFK	hsa-miR-1297	92.9946	NM_018339
RFK	hsa-miR-26a-5p	91.9954	NM_018339
RFK	hsa-miR-26b-5p	91.9954	NM_018339
RFK	hsa-miR-30d-3p	91.4126	NM_018339
RFK	hsa-miR-30e-3p	91.4126	NM_018339
RFK	hsa-miR-30a-3p	91.4126	NM_018339
RFK	hsa-miR-4465	90.8719	NM_018339
RFK	hsa-miR-4252	90.0033	NM_018339
RFK	hsa-miR-196a-1-3p	89.7559	NM_018339
RFK	hsa-miR-1284	89.6932	NM_018339
RFK	hsa-miR-498-5p	88.7044	NM_018339
RFK	hsa-miR-4789-5p	87.4854	NM_018339
RFK	hsa-miR-6783-5p	86.9589	NM_018339
RFK	hsa-miR-195-5p	86.374	NM_018339
RFK	hsa-miR-16-5p	86.374	NM_018339
RFK	hsa-miR-15b-5p	86.374	NM_018339
RFK	hsa-miR-15a-5p	86.374	NM_018339
RFK	hsa-miR-570-3p	85.8561	NM_018339
RFK	hsa-miR-4672	85.4867	NM_018339
RFK	hsa-miR-4473	85.4816	NM_018339
RFK	hsa-miR-8068	85.1155	NM_018339
RFK	hsa-miR-410-3p	84.0201	NM_018339
RFK	hsa-miR-374a-5p	83.8152	NM_018339
RFK	hsa-miR-4666a-3p	83.1866	NM_018339
RFK	hsa-miR-6512-5p	82.9246	NM_018339
RFK	hsa-miR-8057	82.8883	NM_018339
RFK	hsa-miR-424-5p	82.5103	NM_018339
RFK	hsa-miR-6838-5p	82.5103	NM_018339
RFK	hsa-miR-497-5p	82.5103	NM_018339
RFK	hsa-miR-340-5p	82.4283	NM_018339
RFK	hsa-miR-603	82.3169	NM_018339
RFK	hsa-miR-202-5p	81.8324	NM_018339
RFK	hsa-miR-374b-5p	81.1114	NM_018339
RFK	hsa-miR-3148	80.7736	NM_018339

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Motifs and transcription factors (TFs) regulating RFK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RFK	metacluster_151.2	ZNF23 (directAnnotation).
RFK	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RFK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RFK	hdpi__ETV4	ETV4 (directAnnotation).
RFK	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RFK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RFK	hdpi__TP73	TP73 (directAnnotation).
RFK	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RFK	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RFK	cisbp__M08198	ELF1 (directAnnotation).
RFK	hdpi__ELF2	ELF2 (directAnnotation).
RFK	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RFK	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
RFK	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
RFK	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RFK	tfdimers__MD00483	ZBTB14 (directAnnotation).
RFK	cisbp__M07938	E2F1 (directAnnotation).
RFK	cisbp__M00968	MTF2 (directAnnotation).
RFK	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RFK	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RFK	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RFK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RFK	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RFK	"Flavin mononucleotide"	DB03247	small molecule
RFK	"Riboflavin"	DB00140	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."