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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: REV1

Summary for REV1

Gene information	Gene symbol	REV1
	Ensembl ID	ENSG00000135945
	Entrez ID	51455
	Gene name	REV1 DNA directed polymerase
	Synonyms	REV1L
	Gene type	protein_coding
	UniProtAcc	Q9UBZ9

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Dataset with differentially expressed gene: REV1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.254078	0.00e+00

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Expression of REV1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to REV1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
REV1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating REV1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
REV1	hsa-miR-548c-3p	98.4052	NM_016316
REV1	hsa-miR-96-5p	95.6844	NM_001037872
REV1	hsa-miR-1271-5p	95.174	NM_001037872
REV1	hsa-miR-12133	95.174	NM_001037872
REV1	hsa-miR-182-5p	93.8508	NM_001037872
REV1	hsa-miR-4803	91.9638	NM_016316
REV1	hsa-miR-183-5p	91.3225	NM_016316
REV1	hsa-miR-484	90.7777	NM_001037872
REV1	hsa-miR-888-3p	90.3793	NM_016316
REV1	hsa-miR-7162-5p	90.0484	NM_016316
REV1	hsa-miR-516b-3p	90.0484	NM_016316
REV1	hsa-miR-516a-3p	90.0484	NM_016316
REV1	hsa-miR-5688	88.7698	NM_016316
REV1	hsa-miR-495-3p	88.2226	NM_016316
REV1	hsa-miR-3155a	87.2525	NM_001037872
REV1	hsa-miR-3155b	87.2525	NM_001037872
REV1	hsa-miR-3121-3p	86.3278	NM_016316
REV1	hsa-miR-548v	86.239	NM_016316
REV1	hsa-miR-548aj-3p	85.8706	NM_001037872
REV1	hsa-miR-548x-3p	85.8706	NM_001037872
REV1	hsa-let-7c-3p	85.8018	NM_001037872
REV1	hsa-miR-5582-3p	85.2814	NM_016316
REV1	hsa-miR-4668-3p	85.1419	NM_016316
REV1	hsa-miR-7856-5p	85.133	NM_001037872
REV1	hsa-miR-125b-2-3p	85.0998	NM_001037872
REV1	hsa-miR-4457	85.0998	NM_001037872
REV1	hsa-miR-582-5p	84.3603	NM_001037872
REV1	hsa-miR-548j-3p	84.1539	NM_001037872
REV1	hsa-miR-4426	83.706	NM_016316
REV1	hsa-miR-513b-5p	82.8577	NM_001037872
REV1	hsa-miR-6840-3p	81.7705	NM_016316
REV1	hsa-miR-548ae-3p	81.6619	NM_001037872
REV1	hsa-miR-548ah-3p	81.6619	NM_001037872
REV1	hsa-miR-548aq-3p	81.6619	NM_001037872
REV1	hsa-miR-548am-3p	81.6619	NM_001037872
REV1	hsa-miR-1206	81.55	NM_016316
REV1	hsa-miR-545-5p	80.6779	NM_016316
REV1	hsa-miR-4647	80.1406	NM_016316
REV1	hsa-miR-4662b	80.1406	NM_016316

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Motifs and transcription factors (TFs) regulating REV1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
REV1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
REV1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
REV1	transfac_pro__M07397	ZNF148 (directAnnotation).
REV1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
REV1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
REV1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
REV1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
REV1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
REV1	metacluster_7.13	ZFX (directAnnotation).
REV1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
REV1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
REV1	transfac_pro__M01175	ZBTB7B (directAnnotation).
REV1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
REV1	tfdimers__MD00151	CHURC1 (directAnnotation).
REV1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
REV1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
REV1	transfac_pro__M01303	SP1 (directAnnotation).
REV1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
REV1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
REV1	transfac_pro__M02090	E2F4 (directAnnotation).
REV1	transfac_pro__M01714	KLF15 (directAnnotation).
REV1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
REV1	jaspar__MA1122.1	TFDP1 (directAnnotation).
REV1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
REV1	transfac_pro__M02089	E2F3 (directAnnotation).
REV1	transfac_pro__M12604	ZNF444 (directAnnotation).
REV1	metacluster_3.14	WT1; WT1 (directAnnotation).
REV1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
REV1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
REV1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
REV1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
REV1	cisbp__M07938	E2F1 (directAnnotation).
REV1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
REV1	transfac_pro__M07436	WT1 (directAnnotation).
REV1	transfac_pro__M02281	SP1 (directAnnotation).
REV1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
REV1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
REV1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
REV1	transfac_pro__M02898	SMAD3 (directAnnotation).
REV1	transfac_public__M00491	PATZ1 (directAnnotation).
REV1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
REV1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."