DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: REST

Summary for REST

Gene informationGene symbol

REST

Ensembl ID

ENSG00000084093

Entrez ID

5978

Gene nameRE1 silencing transcription factor
SynonymsDFNA27|NRSF|XBR
Gene typeprotein_coding
UniProtAcc

NA


Top

Dataset with differentially expressed gene: REST

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.3917110.00e+00

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.2854796.89e-15

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells-0.3243620.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.3535821.98e-33

Top

Expression of REST in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to REST

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating REST

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RESThsa-miR-520f-5p99.3388NM_001193508
RESThsa-miR-316399.3185NM_001193508
RESThsa-miR-5582-3p98.5186NM_001193508
RESThsa-miR-106b-5p98.1461NM_001193508
RESThsa-miR-20a-5p98.1461NM_001193508
RESThsa-miR-442298.1416NM_001193508
RESThsa-miR-20b-5p97.9487NM_001193508
RESThsa-miR-519d-3p97.7957NM_001193508
RESThsa-miR-548c-3p97.7697NM_001193508
RESThsa-miR-498-3p97.7385NM_001193508
RESThsa-miR-17-5p97.7047NM_001193508
RESThsa-miR-93-5p97.7047NM_001193508
RESThsa-miR-526b-3p97.6452NM_001193508
RESThsa-miR-106a-5p97.6452NM_001193508
RESThsa-miR-6835-3p97.3427NM_001193508
RESThsa-miR-4796-3p96.8282NM_001193508
RESThsa-miR-548ah-5p96.5906NM_001193508
RESThsa-miR-360996.5906NM_001193508
RESThsa-miR-29a-3p95.9982NM_001193508
RESThsa-miR-29b-3p95.9982NM_001193508
RESThsa-miR-29c-3p95.9982NM_001193508
RESThsa-miR-32-5p95.7193NM_001193508
RESThsa-miR-364695.227NM_001193508
RESThsa-miR-480395.0972NM_001193508
RESThsa-miR-129795.0723NM_001193508
RESThsa-miR-92a-3p95.0208NM_001193508
RESThsa-miR-92b-3p95.0208NM_001193508
RESThsa-miR-335-3p94.9834NM_001193508
RESThsa-miR-9-3p94.339NM_001193508
RESThsa-miR-471994.3274NM_001193508
RESThsa-miR-56894.2771NM_001193508
RESThsa-miR-44894.0322NM_001193508
RESThsa-miR-524-5p93.7917NM_001193508
RESThsa-miR-520d-5p93.7917NM_001193508
RESThsa-miR-4666b93.7433NM_001193508
RESThsa-miR-7853-5p93.6958NM_001193508
RESThsa-miR-105-5p93.6958NM_001193508
RESThsa-miR-29b-1-5p93.5535NM_001193508
RESThsa-miR-25-3p93.5423NM_001193508
RESThsa-miR-363-3p93.5423NM_001193508
RESThsa-miR-367-3p93.5423NM_001193508
RESThsa-miR-314893.4932NM_001193508
RESThsa-miR-431993.3518NM_001193508
RESThsa-miR-446592.9372NM_001193508
RESThsa-miR-26a-5p92.6403NM_001193508
RESThsa-miR-26b-5p92.6403NM_001193508
RESThsa-miR-125b-5p92.2665NM_001193508
RESThsa-miR-125a-5p92.2665NM_001193508
RESThsa-miR-6851-3p91.0794NM_001193508
RESThsa-miR-29a-5p90.3535NM_001193508
Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating REST

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RESTmetacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RESTmetacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RESTtaipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_reprERF; FOXI1 (directAnnotation).
RESTtransfac_pro__M04826EP300 (directAnnotation).
RESTmetacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RESTtaipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
RESTtransfac_pro__M00652NRF1 (directAnnotation).
RESThdpi__ETV4ETV4 (directAnnotation).
RESTdbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
RESTtaipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAPFLI1; FOXI1 (directAnnotation).
RESTtaipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAPELK1; FOXI1 (directAnnotation).
RESTjaspar__MA1933.1SREBF2 (directAnnotation).
RESTcisbp__M08198ELF1 (directAnnotation).
RESTdbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3ZNF121 (directAnnotation).
RESTmetacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RESTtaipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAPETV2; FOXO6 (directAnnotation).
RESTtaipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_reprELK1; EOMES (directAnnotation).
RESTtaipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAPELK1; EOMES (directAnnotation).
RESTjaspar__MA1957.1ELK1 (directAnnotation).
RESTtransfac_pro__M06331ZNF343 (directAnnotation).
RESTmetacluster_135.11NR2C2 (directAnnotation).
RESTmetacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RESTtfdimers__MD00038TFAP2C (directAnnotation).
RESTmetacluster_144.3ZNF704; ZNF704 (directAnnotation).
RESTmetacluster_7.13ZFX (directAnnotation).
RESTkznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
RESTcisbp__M00968MTF2 (directAnnotation).
RESTmetacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RESTcisbp__M00341PAX6 (directAnnotation).
RESTmetacluster_198.3ZFP64 (directAnnotation).
RESTmetacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RESTjaspar__MA0185.1DEAF1 (inferredBy_Orthology).
RESTmetacluster_61.1DEAF1; DEAF1 (directAnnotation).
RESTcisbp__M00788ZFY (inferredBy_Orthology).
RESThdpi__ZNF304ZNF304 (directAnnotation).
RESTtransfac_pro__M02844BCL6B (inferredBy_Orthology).
RESTmetacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RESTmetacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RESTtransfac_pro__M01199TRIM28 (directAnnotation).
RESTkznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
RESTmetacluster_151.2ZNF23 (directAnnotation).
RESTtransfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RESTtransfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RESTtransfac_pro__M03806ZBTB7C (directAnnotation).
RESTtransfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RESTtransfac_pro__M01090SMAD9 (inferredBy_Orthology).
RESTflyfactorsurvey__Mad_FlyReg_FBgn0011648SMAD9 (inferredBy_Orthology).
RESTmetacluster_126.3LIN28B; LIN28B (directAnnotation).
RESTtransfac_pro__M04893TAF1 (directAnnotation).
RESThdpi__HIP2UBE2K (directAnnotation).
Page: 1 2

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."