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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RERG

Summary for RERG

Gene information	Gene symbol	RERG
	Ensembl ID	ENSG00000134533
	Entrez ID	85004
	Gene name	RAS like estrogen regulated growth inhibitor
	Synonyms	MGC15754
	Gene type	protein_coding
	UniProtAcc	Q96A58

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Dataset with differentially expressed gene: RERG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.506676	0.00e+00

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Expression of RERG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RERG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RERG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RERG	hsa-miR-5590-3p	96.8301	NM_001190726
RERG	hsa-miR-142-5p	96.8301	NM_001190726
RERG	hsa-miR-6165	96.7651	NM_001190726
RERG	hsa-miR-5011-5p	96.6928	NM_001190726
RERG	hsa-miR-10393-5p	95.9667	NM_032918
RERG	hsa-miR-4495	94.7261	NM_032918
RERG	hsa-miR-135a-3p	91.549	NM_001190726
RERG	hsa-miR-380-3p	91.3914	NM_032918
RERG	hsa-miR-379-3p	91.3914	NM_032918
RERG	hsa-miR-411-3p	91.3914	NM_032918
RERG	hsa-miR-5584-5p	91.2001	NM_032918
RERG	hsa-miR-586	90.3188	NM_001190726
RERG	hsa-miR-5580-3p	89.9239	NM_032918
RERG	hsa-miR-6789-5p	87.448	NM_001190726
RERG	hsa-miR-4714-3p	85.5202	NM_032918
RERG	hsa-miR-3658	83.9858	NM_032918
RERG	hsa-miR-935	83.6431	NM_032918
RERG	hsa-miR-6870-5p	83.2378	NM_032918
RERG	hsa-miR-7111-5p	83.2378	NM_032918
RERG	hsa-miR-5698	83.2378	NM_032918
RERG	hsa-miR-4723-5p	83.2378	NM_032918
RERG	hsa-miR-4470	83.1423	NM_032918
RERG	hsa-miR-4688	83.0366	NM_032918
RERG	hsa-miR-3163	82.8839	NM_032918
RERG	hsa-miR-3179	81.9548	NM_032918
RERG	hsa-miR-203a-3p	81.1902	NM_001190726
RERG	hsa-miR-4443	81.1877	NM_032918
RERG	hsa-miR-223-3p	81.1564	NM_032918

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Motifs and transcription factors (TFs) regulating RERG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."