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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: REPS2

Summary for REPS2

Gene information	Gene symbol	REPS2
	Ensembl ID	ENSG00000169891
	Entrez ID	9185
	Gene name	RALBP1 associated Eps domain containing 2
	Synonyms	POB1
	Gene type	protein_coding
	UniProtAcc	Q8NFH8

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Dataset with differentially expressed gene: REPS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.290738	0.00e+00

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Expression of REPS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to REPS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating REPS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
REPS2	hsa-miR-4262	99.545	NM_004726
REPS2	hsa-miR-4284	99.3599	NM_001080975
REPS2	hsa-miR-181a-5p	99.1663	NM_004726
REPS2	hsa-miR-181b-5p	99.1663	NM_004726
REPS2	hsa-miR-181d-5p	99.1663	NM_004726
REPS2	hsa-miR-181c-5p	99.1663	NM_004726
REPS2	hsa-miR-8063	98.8776	NM_001080975
REPS2	hsa-miR-606	98.7169	NM_001080975
REPS2	hsa-miR-1305	98.6453	NM_001080975
REPS2	hsa-miR-23c	97.9184	NM_004726
REPS2	hsa-miR-7159-5p	97.8925	NM_004726
REPS2	hsa-miR-3613-3p	97.8634	NM_004726
REPS2	hsa-miR-149-5p	97.6758	NM_001080975
REPS2	hsa-miR-23a-3p	97.5072	NM_004726
REPS2	hsa-miR-23b-3p	97.5072	NM_004726
REPS2	hsa-miR-3692-5p	97.2068	NM_004726
REPS2	hsa-miR-548e-5p	96.9381	NM_004726
REPS2	hsa-miR-3064-5p	96.9143	NM_001080975
REPS2	hsa-miR-3085-3p	96.9143	NM_001080975
REPS2	hsa-miR-6504-5p	96.9143	NM_001080975
REPS2	hsa-miR-6882-5p	94.3852	NM_001080975
REPS2	hsa-miR-4698	94.3366	NM_001080975
REPS2	hsa-miR-5692a	93.9935	NM_001080975
REPS2	hsa-miR-4282	92.1605	NM_004726
REPS2	hsa-miR-218-5p	92.045	NM_001080975
REPS2	hsa-miR-6077	91.9961	NM_004726
REPS2	hsa-miR-4793-5p	91.9895	NM_001080975
REPS2	hsa-miR-1197	91.9016	NM_004726
REPS2	hsa-miR-3065-5p	91.7855	NM_001080975
REPS2	hsa-miR-4272	91.32	NM_004726
REPS2	hsa-miR-487a-3p	90.6949	NM_004726
REPS2	hsa-miR-154-3p	90.6949	NM_004726
REPS2	hsa-miR-6871-3p	90.6896	NM_001080975
REPS2	hsa-miR-6073	90.5971	NM_004726
REPS2	hsa-miR-421	90.3306	NM_004726
REPS2	hsa-miR-3974	89.9982	NM_004726
REPS2	hsa-miR-4766-5p	89.7382	NM_001080975
REPS2	hsa-miR-126-5p	89.7038	NM_001080975
REPS2	hsa-miR-182-5p	89.7011	NM_001080975
REPS2	hsa-miR-4794	89.1002	NM_001080975
REPS2	hsa-miR-4271	88.7081	NM_004726
REPS2	hsa-miR-3671	88.7007	NM_001080975
REPS2	hsa-miR-4795-3p	88.4374	NM_004726
REPS2	hsa-miR-6509-3p	88.3026	NM_004726
REPS2	hsa-miR-664a-5p	88.2546	NM_001080975
REPS2	hsa-miR-3689e	88.1274	NM_004726
REPS2	hsa-miR-3689a-5p	88.1274	NM_004726
REPS2	hsa-miR-3689f	88.1274	NM_004726
REPS2	hsa-miR-3689b-5p	88.1274	NM_004726
REPS2	hsa-miR-3128	88.0781	NM_004726

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Motifs and transcription factors (TFs) regulating REPS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
REPS2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
REPS2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
REPS2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
REPS2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
REPS2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
REPS2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
REPS2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."