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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RELA

Summary for RELA

Gene information	Gene symbol	RELA
	Ensembl ID	ENSG00000173039
	Entrez ID	5970
	Gene name	RELA proto-oncogene, NF-kB subunit
	Synonyms	NFKB3\|p65
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RELA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.459635	0.00e+00

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Expression of RELA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RELA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RELA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RELA	hsa-miR-888-3p	96.4169	NM_021975
RELA	hsa-miR-506-3p	94.8558	NM_001145138
RELA	hsa-miR-124-3p	94.8558	NM_001145138
RELA	hsa-miR-302e	94.2571	NM_021975
RELA	hsa-miR-5000-5p	93.7222	NM_021975
RELA	hsa-miR-7-5p	93.6386	NM_021975
RELA	hsa-miR-302a-3p	90.4731	NM_021975
RELA	hsa-miR-302c-3p	90.4731	NM_021975
RELA	hsa-miR-302b-3p	90.4731	NM_021975
RELA	hsa-miR-302d-3p	90.4731	NM_021975
RELA	hsa-miR-1306-5p	90.3294	NM_001145138
RELA	hsa-miR-545-5p	89.6655	NM_021975
RELA	hsa-miR-3714	89.6307	NM_001145138
RELA	hsa-miR-3910	89.6307	NM_001145138
RELA	hsa-miR-498-3p	89.3239	NM_001145138
RELA	hsa-miR-520b-3p	88.16	NM_021975
RELA	hsa-miR-520d-3p	88.16	NM_021975
RELA	hsa-miR-520c-3p	88.16	NM_021975
RELA	hsa-miR-520e-3p	88.16	NM_021975
RELA	hsa-miR-520a-3p	88.16	NM_021975
RELA	hsa-miR-372-3p	88.16	NM_021975
RELA	hsa-miR-373-3p	88.16	NM_021975
RELA	hsa-miR-5192	88.0959	NM_001145138
RELA	hsa-miR-155-5p	85.7696	NM_001145138
RELA	hsa-miR-3059-3p	85.7243	NM_021975
RELA	hsa-miR-6507-5p	81.009	NM_021975

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Motifs and transcription factors (TFs) regulating RELA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RELA	"Dimethyl fumarate"	DB08908	small molecule
RELA	"Glucosamine"	DB01296	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."