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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RECQL

Summary for RECQL

Gene information	Gene symbol	RECQL
	Ensembl ID	ENSG00000004700
	Entrez ID	5965
	Gene name	RecQ like helicase
	Synonyms	RecQ1\|RecQL1
	Gene type	protein_coding
	UniProtAcc	P46063

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Dataset with differentially expressed gene: RECQL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.27828	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.398862	0.00e+00

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Expression of RECQL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RECQL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RECQL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RECQL	hsa-miR-372-5p	99.2523	NM_002907
RECQL	hsa-miR-548x-3p	96.9738	NM_002907
RECQL	hsa-miR-548aj-3p	96.9738	NM_002907
RECQL	hsa-miR-548an	96.8725	NM_002907
RECQL	hsa-miR-548ae-3p	96.6389	NM_002907
RECQL	hsa-miR-548aq-3p	96.6389	NM_002907
RECQL	hsa-miR-548j-3p	95.6567	NM_002907
RECQL	hsa-miR-548ah-3p	95.6567	NM_002907
RECQL	hsa-miR-548am-3p	95.6567	NM_002907
RECQL	hsa-miR-208b-3p	91.8304	NM_002907
RECQL	hsa-miR-208a-3p	91.8304	NM_002907
RECQL	hsa-miR-548c-3p	90.4901	NM_002907
RECQL	hsa-miR-3910	88.3667	NM_002907
RECQL	hsa-miR-433-3p	86.1501	NM_002907
RECQL	hsa-miR-3613-3p	84.8067	NM_002907
RECQL	hsa-miR-1283	83.0623	NM_002907
RECQL	hsa-miR-3163	82.5059	NM_002907
RECQL	hsa-miR-6780b-3p	80.2915	NM_002907

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Motifs and transcription factors (TFs) regulating RECQL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RECQL	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
RECQL	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
RECQL	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RECQL	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RECQL	cisbp__M08198	ELF1 (directAnnotation).
RECQL	hdpi__ETV4	ETV4 (directAnnotation).
RECQL	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RECQL	jaspar__MA1483.2	ELF2 (directAnnotation).
RECQL	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RECQL	transfac_pro__M04748	GABPA (directAnnotation).
RECQL	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
RECQL	transfac_pro__M05697	ZNF235 (directAnnotation).
RECQL	jaspar__MA1708.1	ETV7 (directAnnotation).
RECQL	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
RECQL	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
RECQL	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."