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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RECK

Summary for RECK

Gene information	Gene symbol	RECK
	Ensembl ID	ENSG00000122707
	Entrez ID	8434
	Gene name	reversion inducing cysteine rich protein with kazal motifs
	Synonyms	hRECK\|ST15
	Gene type	protein_coding
	UniProtAcc	O95980

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Dataset with differentially expressed gene: RECK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.315876	0.00e+00

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Expression of RECK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RECK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RECK	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RECK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RECK	hsa-miR-4795-3p	99.5404	NM_001316346
RECK	hsa-miR-429	98.9259	NM_001316345
RECK	hsa-miR-200b-3p	98.9259	NM_001316345
RECK	hsa-miR-200c-3p	98.9259	NM_001316345
RECK	hsa-miR-5689	98.1836	NM_001316345
RECK	hsa-miR-424-5p	97.9108	NM_001316345
RECK	hsa-miR-6838-5p	97.9108	NM_001316345
RECK	hsa-miR-195-5p	97.7871	NM_001316345
RECK	hsa-miR-16-5p	97.7871	NM_001316345
RECK	hsa-miR-497-5p	97.6122	NM_001316345
RECK	hsa-miR-15a-5p	97.58	NM_001316345
RECK	hsa-miR-15b-5p	97.58	NM_001316345
RECK	hsa-miR-3163	96.7772	NM_001316345
RECK	hsa-miR-4803	96.141	NM_001316347
RECK	hsa-miR-4524a-5p	95.8274	NM_001316345
RECK	hsa-miR-4524b-5p	95.8274	NM_001316345
RECK	hsa-miR-6766-3p	95.1976	NM_001316345
RECK	hsa-miR-219a-5p	95.1976	NM_001316345
RECK	hsa-miR-4782-3p	95.1976	NM_001316345
RECK	hsa-miR-301b-5p	94.1245	NM_001316347
RECK	hsa-miR-301a-5p	94.1245	NM_001316347
RECK	hsa-miR-503-5p	93.9964	NM_001316345
RECK	hsa-miR-371b-3p	93.9836	NM_001316345
RECK	hsa-miR-646	93.8932	NM_001316345
RECK	hsa-miR-29a-5p	93.0619	NM_001316346
RECK	hsa-miR-508-3p	91.9838	NM_001316345
RECK	hsa-miR-216a-3p	91.3228	NM_001316346
RECK	hsa-miR-128-3p	91.3228	NM_001316346
RECK	hsa-miR-182-5p	91.1814	NM_001316345
RECK	hsa-miR-126-5p	91.051	NM_001316346
RECK	hsa-miR-21-5p	90.8794	NM_001316345
RECK	hsa-miR-205-3p	90.5311	NM_001316345
RECK	hsa-miR-4445-5p	90.4114	NM_001316345
RECK	hsa-miR-6504-3p	90.3273	NM_001316346
RECK	hsa-miR-4730	90.1207	NM_001316345
RECK	hsa-miR-3681-3p	89.315	NM_001316346
RECK	hsa-miR-489-3p	89.1749	NM_001316346
RECK	hsa-miR-8485	88.6813	NM_001316345
RECK	hsa-miR-590-5p	87.2879	NM_001316345
RECK	hsa-miR-10399-5p	87.1223	NM_001316346
RECK	hsa-miR-4262	87.0132	NM_001316345
RECK	hsa-let-7f-2-3p	86.825	NM_001316345
RECK	hsa-miR-1185-2-3p	86.825	NM_001316345
RECK	hsa-miR-1185-1-3p	86.825	NM_001316345
RECK	hsa-miR-1277-5p	86.7919	NM_001316345
RECK	hsa-miR-3686	86.3747	NM_001316345
RECK	hsa-miR-5011-5p	86.2402	NM_001316345
RECK	hsa-miR-6516-3p	85.9334	NM_001316345
RECK	hsa-miR-4685-3p	85.431	NM_001316345
RECK	hsa-miR-4287	85.431	NM_001316345

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Motifs and transcription factors (TFs) regulating RECK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RECK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RECK	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RECK	transfac_pro__M04826	EP300 (directAnnotation).
RECK	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RECK	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RECK	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RECK	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
RECK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RECK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RECK	jaspar__MA1122.1	TFDP1 (directAnnotation).
RECK	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RECK	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RECK	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RECK	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
RECK	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."