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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RDH10

Summary for RDH10

Gene information	Gene symbol	RDH10
	Ensembl ID	ENSG00000121039
	Entrez ID	157506
	Gene name	retinol dehydrogenase 10
	Synonyms	SDR16C4
	Gene type	protein_coding
	UniProtAcc	Q8IZV5

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Dataset with differentially expressed gene: RDH10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.744568	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.298495	2.98e-06
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.5361	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.659954	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.511805	1.72e-36

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Expression of RDH10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RDH10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RDH10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RDH10	hsa-miR-4715-5p	97.213	NM_172037
RDH10	hsa-miR-6831-5p	95.6744	NM_172037
RDH10	hsa-miR-494-3p	95.4673	NM_172037
RDH10	hsa-miR-3613-3p	95.0439	NM_172037
RDH10	hsa-miR-3927-3p	94.3913	NM_172037
RDH10	hsa-miR-4684-5p	92.4623	NM_172037
RDH10	hsa-miR-3646	91.7349	NM_172037
RDH10	hsa-miR-5688	90.1453	NM_172037
RDH10	hsa-miR-3074-3p	89.4165	NM_172037
RDH10	hsa-miR-4650-3p	88.4438	NM_172037
RDH10	hsa-miR-4534	87.2225	NM_172037
RDH10	hsa-miR-12136	86.9034	NM_172037
RDH10	hsa-miR-495-3p	86.8312	NM_172037
RDH10	hsa-miR-506-3p	86.366	NM_172037
RDH10	hsa-miR-124-3p	86.366	NM_172037
RDH10	hsa-miR-10397-5p	86.2825	NM_172037
RDH10	hsa-miR-4756-3p	86.2054	NM_172037
RDH10	hsa-miR-8082	86.0255	NM_172037
RDH10	hsa-miR-200c-3p	85.8013	NM_172037
RDH10	hsa-miR-200b-3p	85.8013	NM_172037
RDH10	hsa-miR-429	85.8013	NM_172037
RDH10	hsa-miR-4311	84.6286	NM_172037
RDH10	hsa-miR-561-5p	83.73	NM_172037
RDH10	hsa-miR-630	82.9176	NM_172037
RDH10	hsa-miR-4286	82.4435	NM_172037
RDH10	hsa-miR-3164	82.2425	NM_172037
RDH10	hsa-miR-6820-3p	82.2425	NM_172037
RDH10	hsa-miR-5001-3p	82.0531	NM_172037
RDH10	hsa-miR-8485	81.4082	NM_172037
RDH10	hsa-miR-4777-5p	81.1632	NM_172037
RDH10	hsa-miR-1910-5p	81.0199	NM_172037

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Motifs and transcription factors (TFs) regulating RDH10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RDH10	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
RDH10	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
RDH10	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
RDH10	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
RDH10	metacluster_35.7	HINFP (inferredBy_Orthology).
RDH10	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RDH10	dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1	E4F1 (directAnnotation).
RDH10	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
RDH10	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RDH10	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RDH10	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
RDH10	hdpi__TP73	TP73 (directAnnotation).
RDH10	hdpi__MYEF2	MYEF2 (directAnnotation).
RDH10	metacluster_131.6	EGR2; EGR4 (directAnnotation). EGR2; EGR3 (inferredBy_Orthology).
RDH10	transfac_pro__M04886	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."