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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCSD1

Summary for RCSD1

Gene information	Gene symbol	RCSD1
	Ensembl ID	ENSG00000198771
	Entrez ID	92241
	Gene name	RCSD domain containing 1
	Synonyms	CapZIP\|MGC21854\|MK2S4
	Gene type	protein_coding
	UniProtAcc	Q6JBY9

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Dataset with differentially expressed gene: RCSD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.385922	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.334426	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.273459	6.80e-32
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.476299	6.32e-26
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.295483	1.57e-36
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.33105	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.3493	1.17e-36
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.427433	4.98e-06
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.277542	9.57e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.396575	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.49025	1.43e-09
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.478346	8.01e-24
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.258216	1.76e-21
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.481902	0.00e+00

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Expression of RCSD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCSD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCSD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCSD1	hsa-miR-5197-3p	93.728	NM_001322923
RCSD1	hsa-miR-4733-5p	91.7733	NM_052862
RCSD1	hsa-miR-3619-5p	89.6974	NM_052862
RCSD1	hsa-miR-6882-5p	88.7565	NM_052862
RCSD1	hsa-miR-214-3p	87.6076	NM_052862
RCSD1	hsa-miR-761	87.6076	NM_052862
RCSD1	hsa-miR-4649-3p	87.4957	NM_001322923
RCSD1	hsa-miR-7-1-3p	86.6454	NM_001322923
RCSD1	hsa-miR-7-2-3p	86.6454	NM_001322923
RCSD1	hsa-miR-4291	86.0768	NM_052862
RCSD1	hsa-miR-335-3p	85.2996	NM_001322923
RCSD1	hsa-miR-2052	84.0435	NM_052862
RCSD1	hsa-miR-888-5p	83.8636	NM_052862
RCSD1	hsa-miR-3177-5p	83.2979	NM_001322923
RCSD1	hsa-miR-199b-5p	80.4264	NM_052862
RCSD1	hsa-miR-199a-5p	80.4264	NM_052862

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Motifs and transcription factors (TFs) regulating RCSD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCSD1	jaspar__MA1708.1	ETV7 (directAnnotation).
RCSD1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RCSD1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
RCSD1	taipale_tf_pairs__FLI1_DLX2_RSCGGAARYAATTA_CAP	DLX2; FLI1 (directAnnotation).
RCSD1	metacluster_191.1	ZNF528; ZNF528; ZNF528 (directAnnotation).
RCSD1	tfdimers__MD00421	ELF3; POU5F1 (directAnnotation).
RCSD1	swissregulon__mm__Nr4a1	NR4A1 (inferredBy_Orthology).
RCSD1	tfdimers__MD00133	YY1; ZNF333 (directAnnotation).
RCSD1	tfdimers__MD00066	ELF1 (directAnnotation).
RCSD1	transfac_pro__M06007	ZNF69 (directAnnotation).
RCSD1	jaspar__MA1947.1	FOXO1 (directAnnotation).
RCSD1	cisbp__M01815	CEBPE (inferredBy_Orthology).
RCSD1	transfac_pro__M06347	ZNF782 (directAnnotation).
RCSD1	transfac_pro__M05525	ZBTB41 (directAnnotation).
RCSD1	transfac_pro__M05698	ZNF141 (directAnnotation).
RCSD1	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
RCSD1	metacluster_172.29	ZNF131 (directAnnotation). ZNF131 (inferredBy_Orthology).
RCSD1	transfac_pro__M06787	ZNF780B (directAnnotation).
RCSD1	tfdimers__MD00127	HOXA13; TFAP2C (directAnnotation).
RCSD1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
RCSD1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGNNNNNNYMATTA_CAP	ETV2; HOXA2 (directAnnotation).
RCSD1	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
RCSD1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RCSD1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RCSD1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RCSD1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RCSD1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RCSD1	metacluster_55.5	ZNF541 (directAnnotation).
RCSD1	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
RCSD1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
RCSD1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
RCSD1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
RCSD1	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
RCSD1	taipale_tf_pairs__ETV2_HOXB13_NCCGGAAGTYRTAAAN_CAP	ETV2; HOXB13 (directAnnotation).
RCSD1	jaspar__MA1563.2	SOX18 (directAnnotation).
RCSD1	taipale_tf_pairs__ETV2_NHLH1_NCCGGAANNNNNNCAGCTGNN_CAP_repr	ETV2; NHLH1 (directAnnotation).
RCSD1	transfac_pro__M06071	ZNF814 (directAnnotation).
RCSD1	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
RCSD1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RCSD1	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
RCSD1	metacluster_29.6	ZNF436 (directAnnotation).
RCSD1	transfac_pro__M05884	ZNF439 (directAnnotation).
RCSD1	transfac_pro__M05349	SNAI3 (directAnnotation).
RCSD1	tfdimers__MD00222	ASCL1; BHLHE40; BHLHE41; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; HAND1; HAND2; MAX; MITF; MXD1; MXD3; MXD4; MXI1; MYC; MYCN; MYF5; MYF6; MYOD1; MYOG; NHLH1; TAL1; TAL2; TCF12; TCF3; TCF4; TFE3; TFEB; USF1; USF2 (directAnnotation).
RCSD1	transfac_pro__M06146	ZNF45 (directAnnotation).
RCSD1	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNTAATKR_HT	DLX3; TFAP4 (directAnnotation).
RCSD1	tfdimers__MD00241	ISL1; PITX3 (directAnnotation).
RCSD1	metacluster_92.4	ZNF33B (directAnnotation).
RCSD1	metacluster_172.8	SIX1 (directAnnotation).
RCSD1	tfdimers__MD00161	FOS (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."