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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCOR3

Summary for RCOR3

Gene information	Gene symbol	RCOR3
	Ensembl ID	ENSG00000117625
	Entrez ID	55758
	Gene name	REST corepressor 3
	Synonyms	FLJ10876
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RCOR3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.449994	0.00e+00

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Expression of RCOR3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCOR3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCOR3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCOR3	hsa-miR-95-5p	94.9592	NM_001136224
RCOR3	hsa-miR-141-3p	94.02	NM_001136225
RCOR3	hsa-miR-200a-3p	94.02	NM_001136225
RCOR3	hsa-miR-128-3p	93.5611	NM_001136224
RCOR3	hsa-miR-216a-3p	93.5611	NM_001136224
RCOR3	hsa-miR-580-5p	93.0472	NM_001136223
RCOR3	hsa-miR-548ap-3p	92.9833	NM_001136225
RCOR3	hsa-miR-548aa	92.9833	NM_001136225
RCOR3	hsa-miR-548t-3p	92.9833	NM_001136225
RCOR3	hsa-miR-5197-3p	92.837	NM_001136224
RCOR3	hsa-miR-3681-3p	92.7682	NM_001136224
RCOR3	hsa-miR-1468-3p	92.6042	NM_001136223
RCOR3	hsa-miR-302f	91.1087	NM_001136224
RCOR3	hsa-miR-548c-3p	89.6677	NM_001136224
RCOR3	hsa-miR-4477a	88.6714	NM_001136223
RCOR3	hsa-miR-3163	88.4584	NM_001136224
RCOR3	hsa-miR-5684	88.0054	NM_001136223
RCOR3	hsa-miR-500a-5p	87.743	NM_001136224
RCOR3	hsa-miR-3120-5p	87.2259	NM_001136224
RCOR3	hsa-miR-3160-5p	86.945	NM_001136224
RCOR3	hsa-miR-6732-3p	86.5231	NM_001136223
RCOR3	hsa-miR-6885-3p	86.466	NM_001136223
RCOR3	hsa-miR-7159-5p	86.135	NM_001136223
RCOR3	hsa-miR-3119	85.3383	NM_001136224
RCOR3	hsa-miR-3065-5p	85.3273	NM_001136223
RCOR3	hsa-miR-380-3p	84.8584	NM_001136223
RCOR3	hsa-miR-1251-3p	84.8006	NM_001136224
RCOR3	hsa-miR-4804-3p	84.4417	NM_001136225
RCOR3	hsa-miR-3662	84.3831	NM_001136224
RCOR3	hsa-miR-567	83.7171	NM_001136223
RCOR3	hsa-miR-520f-3p	83.5567	NM_001136224
RCOR3	hsa-miR-10525-3p	83.3471	NM_001136225
RCOR3	hsa-miR-675-3p	82.6053	NM_001136223
RCOR3	hsa-miR-590-3p	82.548	NM_001136224
RCOR3	hsa-miR-7856-5p	82.1653	NM_001136223
RCOR3	hsa-miR-888-3p	82.1564	NM_001136223
RCOR3	hsa-miR-4699-3p	82.1408	NM_001136224
RCOR3	hsa-miR-892a	81.9885	NM_001136224
RCOR3	hsa-miR-497-3p	81.68	NM_001136224
RCOR3	hsa-miR-3133	81.5757	NM_001136224
RCOR3	hsa-miR-4477b	81.1114	NM_001136223
RCOR3	hsa-miR-499a-5p	80.9623	NM_001136225
RCOR3	hsa-miR-4704-5p	80.4149	NM_001136223
RCOR3	hsa-miR-27a-3p	80.1449	NM_001136224
RCOR3	hsa-miR-27b-3p	80.1449	NM_001136224
RCOR3	hsa-miR-9985	80.1449	NM_001136224
RCOR3	hsa-miR-561-5p	80.0603	NM_001136223

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Motifs and transcription factors (TFs) regulating RCOR3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCOR3	transfac_pro__M02089	E2F3 (directAnnotation).
RCOR3	transfac_pro__M02898	SMAD3 (directAnnotation).
RCOR3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RCOR3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RCOR3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RCOR3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RCOR3	hdpi__HIP2	UBE2K (directAnnotation).
RCOR3	hdpi__NRL	NRL (directAnnotation).
RCOR3	transfac_pro__M00430	E2F1 (directAnnotation).
RCOR3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RCOR3	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
RCOR3	transfac_pro__M07329	SP7 (directAnnotation).
RCOR3	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
RCOR3	transfac_pro__M07397	ZNF148 (directAnnotation).
RCOR3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCOR3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RCOR3	cisbp__M07938	E2F1 (directAnnotation).
RCOR3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RCOR3	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RCOR3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RCOR3	transfac_pro__M07436	WT1 (directAnnotation).
RCOR3	metacluster_3.14	WT1; WT1 (directAnnotation).
RCOR3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RCOR3	transfac_pro__M01837	KLF11 (directAnnotation).
RCOR3	hdpi__TP73	TP73 (directAnnotation).
RCOR3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RCOR3	transfac_pro__M07310	SP5 (directAnnotation).
RCOR3	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RCOR3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RCOR3	transfac_pro__M04817	ZBTB33 (directAnnotation).
RCOR3	jaspar__MA0748.2	YY2 (directAnnotation).
RCOR3	swissregulon__hs__KLF6	KLF6 (directAnnotation).
RCOR3	metacluster_7.13	ZFX (directAnnotation).
RCOR3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RCOR3	transfac_pro__M00716	ZBTB14 (directAnnotation).
RCOR3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RCOR3	jaspar__MA1122.1	TFDP1 (directAnnotation).
RCOR3	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
RCOR3	cisbp__M00968	MTF2 (directAnnotation).
RCOR3	metacluster_163.2	ZNF682 (directAnnotation).
RCOR3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RCOR3	transfac_pro__M04916	TAF1 (directAnnotation).
RCOR3	transfac_pro__M00938	E2F1 (directAnnotation).
RCOR3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RCOR3	transfac_pro__M02090	E2F4 (directAnnotation).
RCOR3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RCOR3	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
RCOR3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RCOR3	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."