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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCN2

Summary for RCN2

Gene information	Gene symbol	RCN2
	Ensembl ID	ENSG00000117906
	Entrez ID	5955
	Gene name	reticulocalbin 2
	Synonyms	E6BP\|ERC-55\|ERC55\|TCBP49
	Gene type	protein_coding
	UniProtAcc	Q14257

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Dataset with differentially expressed gene: RCN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.299863	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.266747	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.373492	6.04e-15
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.467821	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.560259	0.00e+00

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Expression of RCN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCN2	hsa-miR-12135	98.6143	NM_002902
RCN2	hsa-miR-8087	96.7437	NM_002902
RCN2	hsa-miR-16-2-3p	96.0454	NM_002902
RCN2	hsa-miR-195-3p	96.0454	NM_002902
RCN2	hsa-miR-1297	95.763	NM_001271837
RCN2	hsa-miR-545-5p	94.5378	NM_002902
RCN2	hsa-miR-26b-5p	94.4274	NM_001271837
RCN2	hsa-miR-26a-5p	94.4274	NM_001271837
RCN2	hsa-miR-548aw	94.2442	NM_002902
RCN2	hsa-miR-183-5p	93.8444	NM_002902
RCN2	hsa-miR-539-3p	93.5935	NM_001271837
RCN2	hsa-miR-485-3p	93.5935	NM_001271837
RCN2	hsa-miR-4465	93.1257	NM_001271837
RCN2	hsa-miR-205-3p	92.9194	NM_001271837
RCN2	hsa-miR-138-2-3p	92.7694	NM_002902
RCN2	hsa-miR-4766-5p	91.8385	NM_002902
RCN2	hsa-miR-5692a	90.4584	NM_002902
RCN2	hsa-miR-5580-3p	90.2817	NM_002902
RCN2	hsa-miR-155-5p	89.3418	NM_002902
RCN2	hsa-miR-373-5p	88.3207	NM_001271837
RCN2	hsa-miR-371b-5p	88.3207	NM_001271837
RCN2	hsa-miR-616-5p	88.3207	NM_001271837
RCN2	hsa-miR-6809-3p	88.2473	NM_001271837
RCN2	hsa-miR-499a-5p	88.2274	NM_002902
RCN2	hsa-miR-101-3p	87.9899	NM_002902
RCN2	hsa-miR-5697	87.2803	NM_001271837
RCN2	hsa-miR-3688-3p	86.5827	NM_002902
RCN2	hsa-miR-30e-3p	86.1562	NM_002902
RCN2	hsa-miR-30a-3p	86.1562	NM_002902
RCN2	hsa-miR-30d-3p	86.1562	NM_002902
RCN2	hsa-miR-133a-5p	85.8227	NM_002902
RCN2	hsa-miR-34b-3p	84.8964	NM_001271837
RCN2	hsa-miR-3692-3p	84.449	NM_002902
RCN2	hsa-miR-9986	83.4198	NM_002902
RCN2	hsa-miR-1294	83.4198	NM_002902
RCN2	hsa-miR-1284	83.3551	NM_002902
RCN2	hsa-miR-4323	83.2676	NM_002902
RCN2	hsa-miR-323a-3p	81.218	NM_001271837
RCN2	hsa-miR-548as-3p	81.1932	NM_002902
RCN2	hsa-miR-320b	80.3668	NM_002902
RCN2	hsa-miR-320d	80.3668	NM_002902
RCN2	hsa-miR-4429	80.3668	NM_002902
RCN2	hsa-miR-320c	80.3668	NM_002902
RCN2	hsa-miR-320a-3p	80.3668	NM_002902
RCN2	hsa-miR-223-3p	80.3026	NM_002902

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Motifs and transcription factors (TFs) regulating RCN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCN2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RCN2	metacluster_3.14	WT1; WT1 (directAnnotation).
RCN2	transfac_pro__M04706	RELA (directAnnotation).
RCN2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RCN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RCN2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RCN2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RCN2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RCN2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RCN2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RCN2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RCN2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RCN2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RCN2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RCN2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
RCN2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
RCN2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RCN2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RCN2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RCN2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
RCN2	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
RCN2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RCN2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
RCN2	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
RCN2	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
RCN2	cisbp__M07938	E2F1 (directAnnotation).
RCN2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RCN2	hdpi__HIP2	UBE2K (directAnnotation).
RCN2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCN2	transfac_pro__M07436	WT1 (directAnnotation).
RCN2	jaspar__MA0748.2	YY2 (directAnnotation).
RCN2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RCN2	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."