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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCHY1

Summary for RCHY1

Gene information	Gene symbol	RCHY1
	Ensembl ID	ENSG00000163743
	Entrez ID	25898
	Gene name	ring finger and CHY zinc finger domain containing 1
	Synonyms	ARNIP\|CHIMP\|DKFZp586C1620\|PIRH2\|PRO1996\|RNF199\|ZCHY\|ZNF363
	Gene type	protein_coding
	UniProtAcc	Q96PM5

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Dataset with differentially expressed gene: RCHY1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.299964	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.269733	8.80e-20
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.269806	1.70e-15

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Expression of RCHY1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCHY1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCHY1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCHY1	hsa-miR-3117-5p	99.0401	NM_001278537
RCHY1	hsa-miR-329-5p	95.2784	NM_001278537
RCHY1	hsa-miR-12136	93.4639	NM_001009922
RCHY1	hsa-miR-5692a	92.6542	NM_001009922
RCHY1	hsa-miR-4672	91.3325	NM_001278537
RCHY1	hsa-miR-607	90.2098	NM_001009922
RCHY1	hsa-miR-3163	90.196	NM_001278537
RCHY1	hsa-miR-938	90.0163	NM_001278537
RCHY1	hsa-miR-590-3p	89.973	NM_001009922
RCHY1	hsa-miR-3907	89.5926	NM_001278537
RCHY1	hsa-miR-6504-3p	89.4841	NM_001009922
RCHY1	hsa-miR-10399-5p	89.4841	NM_001009922
RCHY1	hsa-miR-4760-3p	89.3783	NM_001278537
RCHY1	hsa-miR-3168	89.1825	NM_001009922
RCHY1	hsa-miR-4790-3p	88.1807	NM_001278537
RCHY1	hsa-miR-4422	88.1457	NM_001278537
RCHY1	hsa-miR-3925-3p	87.724	NM_001009922
RCHY1	hsa-miR-5011-5p	86.9933	NM_001278537
RCHY1	hsa-miR-3613-3p	86.8887	NM_001278537
RCHY1	hsa-miR-2681-5p	86.5947	NM_001278537
RCHY1	hsa-miR-8080	85.8766	NM_001278537
RCHY1	hsa-miR-302c-5p	84.481	NM_001278537
RCHY1	hsa-miR-4777-3p	83.8036	NM_001278537
RCHY1	hsa-miR-6797-3p	83.6509	NM_001278537
RCHY1	hsa-miR-5700	83.4935	NM_001278537
RCHY1	hsa-miR-4755-3p	81.4836	NM_001278537
RCHY1	hsa-miR-4803	81.2911	NM_001278537
RCHY1	hsa-miR-211-3p	81.2351	NM_001278537
RCHY1	hsa-miR-770-5p	80.7383	NM_001009922
RCHY1	hsa-miR-4712-5p	80.7383	NM_001009922
RCHY1	hsa-miR-376a-2-5p	80.5715	NM_001278537
RCHY1	hsa-miR-3646	80.3953	NM_001009922
RCHY1	hsa-miR-6817-3p	80.2912	NM_001278537

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Motifs and transcription factors (TFs) regulating RCHY1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCHY1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RCHY1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RCHY1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RCHY1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RCHY1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RCHY1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RCHY1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RCHY1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RCHY1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
RCHY1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RCHY1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RCHY1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."