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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCC2

Summary for RCC2

Gene information	Gene symbol	RCC2
	Ensembl ID	ENSG00000281540
	Entrez ID	55920
	Gene name	regulator of chromosome condensation 2
	Synonyms	TD-60
	Gene type	protein_coding
	UniProtAcc	Q9P258

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Dataset with differentially expressed gene: RCC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.411076	1.21e-32
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.277488	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.398482	0.00e+00

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Expression of RCC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCC2	hsa-miR-5011-5p	98.056	NM_001136204
RCC2	hsa-miR-190a-3p	95.9065	NM_001136204
RCC2	hsa-miR-330-3p	94.3608	NM_001136204
RCC2	hsa-miR-10527-5p	93.7498	NM_001136204
RCC2	hsa-miR-3978	92.9465	NM_001136204
RCC2	hsa-miR-5584-5p	92.2371	NM_001136204
RCC2	hsa-miR-4668-5p	90.6249	NM_001136204
RCC2	hsa-miR-3145-5p	89.4261	NM_001136204
RCC2	hsa-miR-196a-5p	89.1448	NM_001136204
RCC2	hsa-miR-196b-5p	89.1448	NM_001136204
RCC2	hsa-miR-1825	88.7639	NM_001136204
RCC2	hsa-miR-6892-5p	88.6593	NM_001136204
RCC2	hsa-miR-153-5p	87.4928	NM_001136204
RCC2	hsa-miR-506-5p	86.7212	NM_001136204
RCC2	hsa-miR-548m	86.6609	NM_001136204
RCC2	hsa-miR-7850-5p	86.57	NM_001136204
RCC2	hsa-miR-4441	86.5346	NM_001136204
RCC2	hsa-miR-5582-3p	85.9541	NM_001136204
RCC2	hsa-miR-4786-5p	83.6962	NM_001136204
RCC2	hsa-miR-6737-5p	83.6459	NM_001136204
RCC2	hsa-miR-6819-5p	83.6459	NM_001136204
RCC2	hsa-miR-5695	83.1842	NM_001136204
RCC2	hsa-miR-3622a-3p	82.6696	NM_001136204
RCC2	hsa-miR-3622b-3p	82.6696	NM_001136204
RCC2	hsa-miR-411-5p	82.128	NM_001136204
RCC2	hsa-miR-1911-3p	81.7762	NM_001136204
RCC2	hsa-miR-608	81.7004	NM_001136204
RCC2	hsa-miR-6812-5p	81.1325	NM_001136204
RCC2	hsa-miR-498-3p	80.8874	NM_001136204
RCC2	hsa-miR-4270	80.6546	NM_001136204
RCC2	hsa-miR-4272	80.5195	NM_001136204
RCC2	hsa-miR-6885-3p	80.3984	NM_001136204
RCC2	hsa-miR-4422	80.1183	NM_001136204

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Motifs and transcription factors (TFs) regulating RCC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCC2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCC2	transfac_pro__M07397	ZNF148 (directAnnotation).
RCC2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RCC2	metacluster_7.13	ZFX (directAnnotation).
RCC2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RCC2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RCC2	transfac_pro__M01175	ZBTB7B (directAnnotation).
RCC2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RCC2	tfdimers__MD00151	CHURC1 (directAnnotation).
RCC2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RCC2	transfac_pro__M01303	SP1 (directAnnotation).
RCC2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RCC2	transfac_pro__M02089	E2F3 (directAnnotation).
RCC2	metacluster_3.14	WT1; WT1 (directAnnotation).
RCC2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RCC2	cisbp__M07938	E2F1 (directAnnotation).
RCC2	transfac_pro__M07436	WT1 (directAnnotation).
RCC2	transfac_pro__M02281	SP1 (directAnnotation).
RCC2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RCC2	transfac_public__M00491	PATZ1 (directAnnotation).
RCC2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RCC2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RCC2	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
RCC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RCC2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RCC2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
RCC2	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
RCC2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RCC2	cisbp__M00249	WT1 (directAnnotation).
RCC2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RCC2	transfac_pro__M01122	ZNF219 (directAnnotation).
RCC2	metacluster_151.2	ZNF23 (directAnnotation).
RCC2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RCC2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RCC2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RCC2	transfac_pro__M01253	CNOT3 (directAnnotation).
RCC2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RCC2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RCC2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RCC2	transfac_pro__M01199	TRIM28 (directAnnotation).
RCC2	tfdimers__MD00391	KLF4 (directAnnotation).
RCC2	cisbp__M00968	MTF2 (directAnnotation).
RCC2	transfac_pro__M12697	ZNF142 (directAnnotation).
RCC2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RCC2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."