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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCBTB2

Summary for RCBTB2

Gene information	Gene symbol	RCBTB2
	Ensembl ID	ENSG00000136161
	Entrez ID	1102
	Gene name	RCC1 and BTB domain containing protein 2
	Synonyms	CHC1L
	Gene type	protein_coding
	UniProtAcc	O95199

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Dataset with differentially expressed gene: RCBTB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.349509	0.00e+00

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Expression of RCBTB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCBTB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCBTB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCBTB2	hsa-miR-1909-5p	94.6872	NM_001286830
RCBTB2	hsa-miR-589-3p	94.573	NM_001286830
RCBTB2	hsa-miR-6722-3p	90.6711	NM_001286830
RCBTB2	hsa-miR-450b-5p	90.1505	NM_001286830
RCBTB2	hsa-miR-556-3p	89.3902	NM_001268
RCBTB2	hsa-miR-1909-3p	88.6935	NM_001286830
RCBTB2	hsa-miR-6809-3p	85.4492	NM_001286830
RCBTB2	hsa-miR-203a-3p	84.422	NM_001268
RCBTB2	hsa-miR-10397-5p	83.9415	NM_001286830
RCBTB2	hsa-miR-6859-5p	82.8363	NM_001286830
RCBTB2	hsa-miR-3916	82.8363	NM_001286830
RCBTB2	hsa-miR-3125	82.8363	NM_001286830
RCBTB2	hsa-miR-12136	82.5672	NM_001286830
RCBTB2	hsa-miR-4329	82.4025	NM_001286830
RCBTB2	hsa-miR-3160-5p	82.2251	NM_001286830

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Motifs and transcription factors (TFs) regulating RCBTB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCBTB2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RCBTB2	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
RCBTB2	transfac_pro__M06894	ZFP90 (inferredBy_Orthology).
RCBTB2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RCBTB2	transfac_pro__M05529	ZBTB5 (inferredBy_Orthology).
RCBTB2	transfac_pro__M00652	NRF1 (directAnnotation).
RCBTB2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RCBTB2	hdpi__MLX	MLX (directAnnotation).
RCBTB2	transfac_pro__M06415	ZNF429 (directAnnotation).
RCBTB2	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
RCBTB2	transfac_pro__M06096	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."