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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RCAN1

Summary for RCAN1

Gene information	Gene symbol	RCAN1
	Ensembl ID	ENSG00000159200
	Entrez ID	1827
	Gene name	regulator of calcineurin 1
	Synonyms	DSCR1
	Gene type	protein_coding
	UniProtAcc	P53805

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Dataset with differentially expressed gene: RCAN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.942926	7.12e-07
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.494438	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.665179	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.526823	1.33e-33
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.440432	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.318715	0.00e+00

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Expression of RCAN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCAN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCAN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCAN1	hsa-miR-6835-3p	95.8255	NM_001285389
RCAN1	hsa-miR-6508-5p	95.1557	NM_001285389
RCAN1	hsa-miR-513a-5p	94.0123	NM_001285389
RCAN1	hsa-miR-4753-5p	93.2323	NM_001285389
RCAN1	hsa-miR-8067	91.3723	NM_001285389
RCAN1	hsa-miR-548e-5p	89.0857	NM_001285389
RCAN1	hsa-miR-219a-2-3p	87.884	NM_001285389
RCAN1	hsa-miR-34a-5p	87.037	NM_001285389
RCAN1	hsa-miR-449a	87.037	NM_001285389
RCAN1	hsa-miR-34c-5p	85.0288	NM_001285389
RCAN1	hsa-miR-449b-5p	85.0288	NM_001285389
RCAN1	hsa-miR-4303	85.0017	NM_001285389
RCAN1	hsa-miR-549a-3p	84.6809	NM_001285389
RCAN1	hsa-miR-3944-5p	84.0256	NM_001285389
RCAN1	hsa-miR-330-3p	83.9035	NM_001285389
RCAN1	hsa-miR-6877-3p	82.3328	NM_001285389
RCAN1	hsa-miR-6819-3p	82.3328	NM_001285389
RCAN1	hsa-miR-545-5p	81.9801	NM_001285389
RCAN1	hsa-miR-6892-3p	81.1017	NM_001285389

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Motifs and transcription factors (TFs) regulating RCAN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCAN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCAN1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RCAN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RCAN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RCAN1	transfac_pro__M02090	E2F4 (directAnnotation).
RCAN1	transfac_pro__M02089	E2F3 (directAnnotation).
RCAN1	metacluster_3.14	WT1; WT1 (directAnnotation).
RCAN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RCAN1	cisbp__M07938	E2F1 (directAnnotation).
RCAN1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RCAN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RCAN1	transfac_pro__M02898	SMAD3 (directAnnotation).
RCAN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RCAN1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RCAN1	transfac_pro__M07436	WT1 (directAnnotation).
RCAN1	transfac_pro__M00716	ZBTB14 (directAnnotation).
RCAN1	hdpi__HIP2	UBE2K (directAnnotation).
RCAN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RCAN1	transfac_pro__M04893	TAF1 (directAnnotation).
RCAN1	transfac_pro__M03876	ZBTB33 (directAnnotation).
RCAN1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RCAN1	hdpi__TFAM	TFAM (directAnnotation).
RCAN1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RCAN1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RCAN1	transfac_pro__M08819	KLF2 (directAnnotation).
RCAN1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
RCAN1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RCAN1	transfac_pro__M00652	NRF1 (directAnnotation).
RCAN1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RCAN1	jaspar__MA1933.1	SREBF2 (directAnnotation).
RCAN1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
RCAN1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
RCAN1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RCAN1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RCAN1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RCAN1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RCAN1	jaspar__MA1708.1	ETV7 (directAnnotation).
RCAN1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
RCAN1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RCAN1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RCAN1	transfac_pro__M04748	GABPA (directAnnotation).
RCAN1	transfac_public__M00041	ATF2; JUN (directAnnotation).
RCAN1	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
RCAN1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RCAN1	"Dipyridamole"	DB00975	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."