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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBPMS

Summary for RBPMS

Gene information	Gene symbol	RBPMS
	Ensembl ID	ENSG00000157110
	Entrez ID	11030
	Gene name	RNA binding protein, mRNA processing factor
	Synonyms	HERMES
	Gene type	protein_coding
	UniProtAcc	Q93062

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Dataset with differentially expressed gene: RBPMS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.08342	1.84e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.45102	4.40e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.684761	0.00e+00

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Expression of RBPMS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBPMS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBPMS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBPMS	hsa-miR-6805-3p	95.9504	NM_001008712
RBPMS	hsa-miR-5691	95.9504	NM_001008712
RBPMS	hsa-miR-548e-5p	93.9028	NM_006867
RBPMS	hsa-miR-1185-1-3p	90.8299	NM_006867
RBPMS	hsa-let-7f-2-3p	90.8299	NM_006867
RBPMS	hsa-miR-1185-2-3p	90.8299	NM_006867
RBPMS	hsa-miR-4282	89.651	NM_001008712
RBPMS	hsa-miR-6864-5p	88.0373	NM_006867
RBPMS	hsa-miR-3920	87.9458	NM_001008712
RBPMS	hsa-miR-6815-3p	87.723	NM_006867
RBPMS	hsa-miR-1305	87.6552	NM_001008710
RBPMS	hsa-miR-4422	87.4814	NM_006867
RBPMS	hsa-miR-6826-5p	86.5501	NM_001008710
RBPMS	hsa-miR-6847-5p	85.5903	NM_001008710
RBPMS	hsa-miR-891b	84.7285	NM_006867
RBPMS	hsa-miR-542-3p	84.4318	NM_001008710
RBPMS	hsa-miR-3925-3p	84.2524	NM_006867
RBPMS	hsa-miR-4635	84.0774	NM_006867
RBPMS	hsa-miR-6511a-3p	83.735	NM_006867
RBPMS	hsa-miR-6511b-3p	83.735	NM_006867
RBPMS	hsa-miR-6795-5p	83.5004	NM_001008712
RBPMS	hsa-miR-6887-5p	83.5004	NM_001008712
RBPMS	hsa-miR-199b-5p	81.9329	NM_006867
RBPMS	hsa-miR-199a-5p	81.9329	NM_006867
RBPMS	hsa-miR-6818-5p	81.1843	NM_006867

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Motifs and transcription factors (TFs) regulating RBPMS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBPMS	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RBPMS	transfac_pro__M04617	ZBTB7A (directAnnotation).
RBPMS	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RBPMS	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RBPMS	transfac_pro__M07387	ZBTB7A (directAnnotation).
RBPMS	transfac_pro__M00716	ZBTB14 (directAnnotation).
RBPMS	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RBPMS	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RBPMS	transfac_pro__M04893	TAF1 (directAnnotation).
RBPMS	transfac_pro__M03876	ZBTB33 (directAnnotation).
RBPMS	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RBPMS	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RBPMS	metacluster_135.11	NR2C2 (directAnnotation).
RBPMS	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RBPMS	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RBPMS	metacluster_7.13	ZFX (directAnnotation).
RBPMS	cisbp__M00968	MTF2 (directAnnotation).
RBPMS	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RBPMS	cisbp__M00341	PAX6 (directAnnotation).
RBPMS	metacluster_198.3	ZFP64 (directAnnotation).
RBPMS	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RBPMS	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RBPMS	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RBPMS	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RBPMS	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RBPMS	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RBPMS	transfac_pro__M01199	TRIM28 (directAnnotation).
RBPMS	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RBPMS	metacluster_151.2	ZNF23 (directAnnotation).
RBPMS	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RBPMS	transfac_pro__M03806	ZBTB7C (directAnnotation).
RBPMS	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RBPMS	transfac_pro__M06173	ZNF85 (directAnnotation).
RBPMS	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RBPMS	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RBPMS	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RBPMS	tfdimers__MD00483	ZBTB14 (directAnnotation).
RBPMS	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RBPMS	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
RBPMS	tfdimers__MD00364	WT1 (directAnnotation).
RBPMS	transfac_pro__M04817	ZBTB33 (directAnnotation).
RBPMS	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RBPMS	transfac_pro__M01253	CNOT3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."