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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBMXL1

Summary for RBMXL1

Gene information	Gene symbol	RBMXL1
	Ensembl ID	ENSG00000213516
	Entrez ID	494115
	Gene name	RBMX like 1
	Synonyms	KAT3
	Gene type	protein_coding
	UniProtAcc	Q96E39

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Dataset with differentially expressed gene: RBMXL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.283413	2.09e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.334961	3.20e-12

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Expression of RBMXL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBMXL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBMXL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBMXL1	hsa-miR-133b	94.9053	NM_001162536
RBMXL1	hsa-miR-133a-3p	94.9053	NM_001162536
RBMXL1	hsa-miR-144-3p	94.8153	NM_019610
RBMXL1	hsa-miR-548t-5p	94.751	NM_019610
RBMXL1	hsa-miR-548az-5p	94.751	NM_019610
RBMXL1	hsa-miR-4684-3p	92.1614	NM_019610
RBMXL1	hsa-miR-548aw	91.0616	NM_019610
RBMXL1	hsa-miR-302c-5p	89.2895	NM_001162536
RBMXL1	hsa-miR-6814-5p	89.0098	NM_019610
RBMXL1	hsa-miR-6867-5p	88.0989	NM_019610
RBMXL1	hsa-miR-29a-5p	86.7249	NM_001162536
RBMXL1	hsa-miR-148a-5p	86.6435	NM_019610
RBMXL1	hsa-miR-1229-5p	86.4047	NM_019610
RBMXL1	hsa-miR-668-3p	84.9269	NM_019610
RBMXL1	hsa-miR-6511a-5p	84.8075	NM_001162536
RBMXL1	hsa-miR-1910-3p	84.8075	NM_001162536
RBMXL1	hsa-miR-3133	83.6496	NM_019610
RBMXL1	hsa-miR-193b-3p	83.1188	NM_019610
RBMXL1	hsa-miR-193a-3p	83.1188	NM_019610
RBMXL1	hsa-miR-4659a-5p	82.2897	NM_019610
RBMXL1	hsa-miR-1288-3p	81.9169	NM_019610
RBMXL1	hsa-miR-4659b-5p	81.2774	NM_019610
RBMXL1	hsa-miR-3529-3p	80.8009	NM_001162536
RBMXL1	hsa-miR-320d	80.4417	NM_019610
RBMXL1	hsa-miR-4429	80.4417	NM_019610
RBMXL1	hsa-miR-320a-3p	80.4417	NM_019610
RBMXL1	hsa-miR-320b	80.4417	NM_019610
RBMXL1	hsa-miR-320c	80.4417	NM_019610
RBMXL1	hsa-miR-153-5p	80.0457	NM_019610

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Motifs and transcription factors (TFs) regulating RBMXL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBMXL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RBMXL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RBMXL1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RBMXL1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RBMXL1	hdpi__TP73	TP73 (directAnnotation).
RBMXL1	jaspar__MA1483.2	ELF2 (directAnnotation).
RBMXL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RBMXL1	transfac_pro__M04826	EP300 (directAnnotation).
RBMXL1	transfac_pro__M04862	NRF1 (directAnnotation).
RBMXL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RBMXL1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
RBMXL1	jaspar__MA0748.2	YY2 (directAnnotation).
RBMXL1	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."