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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBM33

Summary for RBM33

Gene information	Gene symbol	RBM33
	Ensembl ID	ENSG00000184863
	Entrez ID	155435
	Gene name	RNA binding motif protein 33
	Synonyms	DKFZp434D1319\|DKFZp686F102\|MGC20460\|PRR8
	Gene type	protein_coding
	UniProtAcc	Q96EV2

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Dataset with differentially expressed gene: RBM33

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.28169	1.06e-07
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.432925	1.46e-42
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.358235	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.38729	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.324341	4.20e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.255889	0.00e+00

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Expression of RBM33 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBM33

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBM33

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBM33	hsa-miR-377-3p	92.3775	NM_053043
RBM33	hsa-miR-200a-3p	91.0627	NM_053043
RBM33	hsa-miR-141-3p	91.0627	NM_053043
RBM33	hsa-miR-3124-3p	87.0417	NM_053043
RBM33	hsa-miR-6734-3p	86.9849	NM_053043
RBM33	hsa-miR-548aw	83.3727	NM_053043
RBM33	hsa-miR-124-3p	83.1698	NM_053043
RBM33	hsa-miR-506-3p	83.1698	NM_053043
RBM33	hsa-miR-4318	82.9884	NM_053043
RBM33	hsa-miR-938	82.9324	NM_053043
RBM33	hsa-miR-4775	81.4815	NM_053043
RBM33	hsa-miR-545-5p	80.5573	NM_053043
RBM33	hsa-miR-500b-3p	80.496	NM_053043

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Motifs and transcription factors (TFs) regulating RBM33

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBM33	transfac_pro__M01783	SP2 (directAnnotation).
RBM33	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RBM33	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RBM33	cisbp__M00788	ZFY (inferredBy_Orthology).
RBM33	metacluster_7.13	ZFX (directAnnotation).
RBM33	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RBM33	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RBM33	transfac_pro__M02898	SMAD3 (directAnnotation).
RBM33	metacluster_191.5	SPDEF (inferredBy_Orthology).
RBM33	hdpi__TIMELESS	TIMELESS (directAnnotation).
RBM33	cisbp__M00249	WT1 (directAnnotation).
RBM33	hdpi__ZNF304	ZNF304 (directAnnotation).
RBM33	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
RBM33	transfac_pro__M00938	E2F1 (directAnnotation).
RBM33	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RBM33	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RBM33	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
RBM33	transfac_pro__M07483	CXXC1 (directAnnotation).
RBM33	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RBM33	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RBM33	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RBM33	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RBM33	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RBM33	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RBM33	metacluster_175.1	ZNF283 (directAnnotation).
RBM33	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RBM33	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
RBM33	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
RBM33	metacluster_144.13	HIC1; HIC1 (directAnnotation).
RBM33	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
RBM33	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RBM33	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RBM33	transfac_pro__M06646	ZNF607 (directAnnotation).
RBM33	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
RBM33	transfac_pro__M02080	ISL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."