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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBM26

Summary for RBM26

Gene information	Gene symbol	RBM26
	Ensembl ID	ENSG00000139746
	Entrez ID	64062
	Gene name	RNA binding motif protein 26
	Synonyms	ARRS2\|C13orf10\|FLJ20957\|PPP1R132\|PRO1777\|SE70-2\|ZC3H17
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RBM26

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.293026	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.366703	9.59e-17

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Expression of RBM26 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBM26

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBM26

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBM26	hsa-miR-380-3p	99.7793	NM_001286631
RBM26	hsa-miR-627-3p	99.0427	NM_001286631
RBM26	hsa-miR-664a-3p	98.7621	NM_001286631
RBM26	hsa-miR-524-5p	98.4521	NM_001286631
RBM26	hsa-miR-520d-5p	98.4521	NM_001286631
RBM26	hsa-miR-4698	97.0503	NM_001286631
RBM26	hsa-miR-4495	96.8582	NM_001286631
RBM26	hsa-miR-4436b-5p	94.097	NM_001286631
RBM26	hsa-miR-548as-3p	93.9688	NM_001286631
RBM26	hsa-miR-300	92.9111	NM_001286631
RBM26	hsa-miR-381-3p	92.9111	NM_001286631
RBM26	hsa-miR-8084	92.6097	NM_001286631
RBM26	hsa-miR-3140-3p	92.452	NM_001286631
RBM26	hsa-miR-7159-3p	91.9003	NM_001286631
RBM26	hsa-miR-379-3p	91.299	NM_001286631
RBM26	hsa-miR-411-3p	91.299	NM_001286631
RBM26	hsa-miR-216a-5p	90.9614	NM_001286631
RBM26	hsa-miR-570-3p	90.864	NM_001286631
RBM26	hsa-miR-543	89.8306	NM_001286631
RBM26	hsa-miR-8063	89.6833	NM_001286631
RBM26	hsa-miR-12123	86.846	NM_001286631
RBM26	hsa-miR-8055	86.4853	NM_001286631
RBM26	hsa-miR-219b-5p	85.5391	NM_001286631
RBM26	hsa-miR-9898	84.0812	NM_001286631
RBM26	hsa-miR-4725-3p	83.5137	NM_001286631
RBM26	hsa-miR-6780b-5p	83.5137	NM_001286631
RBM26	hsa-miR-8062	83.3778	NM_001286631
RBM26	hsa-miR-4274	83.2016	NM_001286631
RBM26	hsa-miR-548ao-5p	83.0519	NM_001286631
RBM26	hsa-miR-548ax	83.0519	NM_001286631
RBM26	hsa-miR-369-3p	82.7822	NM_001286631
RBM26	hsa-miR-4659a-3p	82.4847	NM_001286631
RBM26	hsa-miR-4659b-3p	82.4847	NM_001286631
RBM26	hsa-miR-6507-5p	80.9867	NM_001286631
RBM26	hsa-miR-7109-5p	80.857	NM_001286631
RBM26	hsa-miR-4477a	80.3441	NM_001286631

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Motifs and transcription factors (TFs) regulating RBM26

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBM26	metacluster_7.13	ZFX (directAnnotation).
RBM26	tfdimers__MD00151	CHURC1 (directAnnotation).
RBM26	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RBM26	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RBM26	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RBM26	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RBM26	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."