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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBM15B

Summary for RBM15B

Gene information	Gene symbol	RBM15B
	Ensembl ID	ENSG00000259956
	Entrez ID	29890
	Gene name	RNA binding motif protein 15B
	Synonyms	HUMAGCGB\|OTT3
	Gene type	protein_coding
	UniProtAcc	Q8NDT2

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Dataset with differentially expressed gene: RBM15B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.450016	0.00e+00

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Expression of RBM15B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBM15B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBM15B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBM15B	hsa-miR-4504	94.153	NM_013286
RBM15B	hsa-miR-542-3p	93.1143	NM_013286
RBM15B	hsa-miR-6715a-3p	90.3511	NM_013286
RBM15B	hsa-miR-758-3p	89.1447	NM_013286
RBM15B	hsa-miR-6715b-3p	88.5439	NM_013286
RBM15B	hsa-miR-888-3p	87.5406	NM_013286
RBM15B	hsa-miR-548c-3p	86.5433	NM_013286
RBM15B	hsa-miR-5088-3p	86.1567	NM_013286
RBM15B	hsa-miR-3613-3p	84.9035	NM_013286
RBM15B	hsa-miR-4704-5p	83.4687	NM_013286
RBM15B	hsa-miR-4511	83.417	NM_013286
RBM15B	hsa-miR-6734-3p	82.8134	NM_013286
RBM15B	hsa-miR-4306	82.442	NM_013286
RBM15B	hsa-miR-3059-3p	82.4038	NM_013286
RBM15B	hsa-miR-5681a	81.2309	NM_013286

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Motifs and transcription factors (TFs) regulating RBM15B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBM15B	cisbp__M08198	ELF1 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."