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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBL2

Summary for RBL2

Gene information	Gene symbol	RBL2
	Ensembl ID	ENSG00000103479
	Entrez ID	5934
	Gene name	RB transcriptional corepressor like 2
	Synonyms	p130\|Rb2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RBL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.89096	7.51e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.374232	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.308184	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.272676	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.424914	1.59e-12
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.315642	6.34e-08
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.259204	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.304842	6.74e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.321413	0.00e+00

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Expression of RBL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBL2	hsa-miR-3163	98.2453	NM_005611
RBL2	hsa-miR-1207-3p	97.2869	NM_005611
RBL2	hsa-miR-20a-5p	96.4666	NM_005611
RBL2	hsa-miR-106b-5p	96.4666	NM_005611
RBL2	hsa-miR-5187-5p	96.3079	NM_005611
RBL2	hsa-miR-4735-5p	96.0039	NM_005611
RBL2	hsa-miR-576-5p	95.9948	NM_005611
RBL2	hsa-miR-106a-5p	95.8171	NM_005611
RBL2	hsa-miR-93-5p	95.8171	NM_005611
RBL2	hsa-miR-17-5p	95.8171	NM_005611
RBL2	hsa-miR-519d-3p	95.8171	NM_005611
RBL2	hsa-miR-20b-5p	95.8171	NM_005611
RBL2	hsa-miR-548e-5p	94.8949	NM_005611
RBL2	hsa-miR-526b-3p	94.5821	NM_005611
RBL2	hsa-miR-6867-3p	93.1152	NM_005611
RBL2	hsa-miR-4469	92.9019	NM_005611
RBL2	hsa-miR-545-3p	92.5189	NM_005611
RBL2	hsa-miR-8062	91.9222	NM_005611
RBL2	hsa-miR-586	91.4062	NM_005611
RBL2	hsa-miR-629-3p	91.0922	NM_005611
RBL2	hsa-miR-3120-3p	90.7783	NM_005611
RBL2	hsa-miR-3143	88.8451	NM_001323608
RBL2	hsa-miR-4667-3p	88.0714	NM_001323608
RBL2	hsa-miR-6839-5p	87.5092	NM_005611
RBL2	hsa-miR-378j	87.5092	NM_005611
RBL2	hsa-miR-4719	87.2683	NM_001323608
RBL2	hsa-miR-6883-3p	87.1612	NM_005611
RBL2	hsa-miR-1185-2-3p	87.1572	NM_005611
RBL2	hsa-let-7f-2-3p	87.1572	NM_005611
RBL2	hsa-miR-1185-1-3p	87.1572	NM_005611
RBL2	hsa-miR-526b-5p	86.9001	NM_001323608
RBL2	hsa-miR-190a-5p	86.4385	NM_001323608
RBL2	hsa-miR-190b-5p	86.4385	NM_001323608
RBL2	hsa-miR-5007-3p	86.1973	NM_005611
RBL2	hsa-miR-1468-3p	85.8983	NM_005611
RBL2	hsa-miR-6856-3p	85.7286	NM_001323608
RBL2	hsa-miR-548d-3p	85.3642	NM_001323608
RBL2	hsa-miR-548bb-3p	85.3642	NM_001323608
RBL2	hsa-miR-548ac	85.3642	NM_001323608
RBL2	hsa-miR-548h-3p	85.3642	NM_001323608
RBL2	hsa-miR-548z	85.3642	NM_001323608
RBL2	hsa-miR-6728-5p	84.743	NM_005611
RBL2	hsa-miR-5579-5p	84.7047	NM_001323608
RBL2	hsa-miR-1250-3p	84.591	NM_001323608
RBL2	hsa-miR-5584-5p	84.2787	NM_005611
RBL2	hsa-miR-3611	83.9451	NM_005611
RBL2	hsa-miR-302c-5p	82.872	NM_001323608
RBL2	hsa-miR-6511b-3p	82.5952	NM_005611
RBL2	hsa-miR-6511a-3p	82.5952	NM_005611
RBL2	hsa-miR-4320	82.078	NM_005611

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Motifs and transcription factors (TFs) regulating RBL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBL2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RBL2	jaspar__MA1483.2	ELF2 (directAnnotation).
RBL2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RBL2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
RBL2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RBL2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
RBL2	taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP	CEBPD; ERF (directAnnotation).
RBL2	transfac_pro__M05668	ZNF154 (directAnnotation).
RBL2	transfac_pro__M05708	ZNF136 (directAnnotation).
RBL2	metacluster_198.3	ZFP64 (directAnnotation).
RBL2	metacluster_141.2	E2F2; E2F3 (directAnnotation).
RBL2	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
RBL2	tfdimers__MD00028	ETS1; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
RBL2	transfac_pro__M06071	ZNF814 (directAnnotation).
RBL2	dbtfbs__ZNF660_HEK293_ENCSR283DOU_merged_N1	ZNF660 (directAnnotation).
RBL2	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
RBL2	metacluster_63.3	RFX1; RFX2; RFX3; RFX3; RFX3; RFX4; RFX4 (directAnnotation). RFX1; RFX1; RFX2; RFX2; RFX2; RFX3; RFX3; RFX4; RFX4; RFX6; RFX6; RFX6; RFX8; RFX8 (inferredBy_Orthology).
RBL2	transfac_pro__M06382	ZNF773 (directAnnotation).
RBL2	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
RBL2	taipale_tf_pairs__TEAD4_ELK3_NCCGGAANNNNNNNMATWCC_CAP_repr	ELK3; TEAD4 (directAnnotation).
RBL2	transfac_pro__M06341	ZNF790 (directAnnotation).
RBL2	transfac_pro__M05628	ZNF735 (directAnnotation).
RBL2	taipale_tf_pairs__ETV2_FOXI1_RSCGGAANNRYMAACAN_CAP	ETV2; FOXI1 (directAnnotation).
RBL2	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	CEBPD; FLI1 (directAnnotation).
RBL2	transfac_pro__M01660	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."