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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBFOX2

Summary for RBFOX2

Gene information	Gene symbol	RBFOX2
	Ensembl ID	ENSG00000277564
	Entrez ID	23543
	Gene name	RNA binding fox-1 homolog 2
	Synonyms	FOX-2\|HNRBP2\|HRNBP2\|RBM9
	Gene type	protein_coding
	UniProtAcc	O43251

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Dataset with differentially expressed gene: RBFOX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.0083	1.09e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.454055	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.38725	0.00e+00

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Expression of RBFOX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBFOX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBFOX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBFOX2	hsa-miR-130a-5p	98.2183	NM_014309
RBFOX2	hsa-miR-211-3p	98.1388	NM_001031695
RBFOX2	hsa-miR-8068	97.996	NM_014309
RBFOX2	hsa-miR-518a-5p	97.9081	NM_014309
RBFOX2	hsa-miR-527	97.9081	NM_014309
RBFOX2	hsa-miR-4728-5p	97.7238	NM_001031695
RBFOX2	hsa-miR-548an	97.2093	NM_001031695
RBFOX2	hsa-miR-6785-5p	97.0474	NM_001031695
RBFOX2	hsa-miR-186-5p	96.8656	NM_001031695
RBFOX2	hsa-miR-5093	96.7571	NM_001031695
RBFOX2	hsa-miR-6752-3p	96.555	NM_001031695
RBFOX2	hsa-miR-3148	96.116	NM_014309
RBFOX2	hsa-miR-202-3p	95.4202	NM_001031695
RBFOX2	hsa-miR-149-3p	95.3114	NM_001031695
RBFOX2	hsa-miR-6883-5p	95.3114	NM_001031695
RBFOX2	hsa-miR-9986	93.8397	NM_014309
RBFOX2	hsa-miR-1294	93.8397	NM_014309
RBFOX2	hsa-miR-3059-5p	93.5847	NM_014309
RBFOX2	hsa-miR-508-3p	92.932	NM_001031695
RBFOX2	hsa-miR-6873-3p	92.8773	NM_014309
RBFOX2	hsa-miR-4500	92.7697	NM_001031695
RBFOX2	hsa-miR-12128	92.7368	NM_001031695
RBFOX2	hsa-miR-3065-3p	92.6465	NM_001031695
RBFOX2	hsa-miR-877-3p	92.6328	NM_001031695
RBFOX2	hsa-miR-12136	92.3147	NM_001031695
RBFOX2	hsa-miR-3714	91.223	NM_014309
RBFOX2	hsa-miR-548n	91.2047	NM_001031695
RBFOX2	hsa-let-7e-5p	90.776	NM_001031695
RBFOX2	hsa-let-7f-5p	90.776	NM_001031695
RBFOX2	hsa-let-7g-5p	90.776	NM_001031695
RBFOX2	hsa-let-7a-5p	90.776	NM_001031695
RBFOX2	hsa-let-7i-5p	90.776	NM_001031695
RBFOX2	hsa-miR-98-5p	90.776	NM_001031695
RBFOX2	hsa-let-7c-5p	90.776	NM_001031695
RBFOX2	hsa-let-7b-5p	90.776	NM_001031695
RBFOX2	hsa-miR-4789-5p	90.5753	NM_014309
RBFOX2	hsa-miR-140-3p	89.7329	NM_001031695
RBFOX2	hsa-let-7d-5p	89.0555	NM_001031695
RBFOX2	hsa-miR-4458	89.0555	NM_001031695
RBFOX2	hsa-miR-6511a-5p	88.7804	NM_014309
RBFOX2	hsa-miR-1910-3p	88.7804	NM_014309
RBFOX2	hsa-miR-324-5p	88.3348	NM_001031695
RBFOX2	hsa-miR-6833-3p	88.1496	NM_014309
RBFOX2	hsa-miR-202-5p	88.0078	NM_001031695
RBFOX2	hsa-miR-3192-3p	87.9873	NM_001031695
RBFOX2	hsa-miR-429	87.9838	NM_001031695
RBFOX2	hsa-miR-200b-3p	87.9838	NM_001031695
RBFOX2	hsa-miR-200c-3p	87.9838	NM_001031695
RBFOX2	hsa-miR-3915	87.7562	NM_014309
RBFOX2	hsa-miR-3175	87.4124	NM_014309

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Motifs and transcription factors (TFs) regulating RBFOX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBFOX2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RBFOX2	metacluster_151.2	ZNF23 (directAnnotation).
RBFOX2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RBFOX2	transfac_pro__M05479	ZNF580 (directAnnotation).
RBFOX2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RBFOX2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RBFOX2	jaspar__MA0079.5	SP1 (directAnnotation).
RBFOX2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RBFOX2	transfac_pro__M04950	EGR1 (directAnnotation).
RBFOX2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RBFOX2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RBFOX2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RBFOX2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RBFOX2	transfac_pro__M00652	NRF1 (directAnnotation).
RBFOX2	transfac_pro__M04866	HDAC2 (directAnnotation).
RBFOX2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RBFOX2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RBFOX2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RBFOX2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RBFOX2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RBFOX2	transfac_pro__M04617	ZBTB7A (directAnnotation).
RBFOX2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RBFOX2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RBFOX2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RBFOX2	transfac_pro__M07387	ZBTB7A (directAnnotation).
RBFOX2	transfac_pro__M07436	WT1 (directAnnotation).
RBFOX2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RBFOX2	transfac_pro__M00716	ZBTB14 (directAnnotation).
RBFOX2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RBFOX2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RBFOX2	transfac_pro__M03876	ZBTB33 (directAnnotation).
RBFOX2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RBFOX2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RBFOX2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RBFOX2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RBFOX2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."