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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBBP6

Summary for RBBP6

Gene information	Gene symbol	RBBP6
	Ensembl ID	ENSG00000122257
	Entrez ID	5930
	Gene name	RB binding protein 6, ubiquitin ligase
	Synonyms	P2P-R\|PACT\|SNAMA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RBBP6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.313885	2.19e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.409333	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.48072	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.255949	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.352838	8.41e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.337595	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.37612	0.00e+00

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Expression of RBBP6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBBP6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBBP6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBBP6	hsa-miR-876-3p	97.5895	NM_006910
RBBP6	hsa-miR-4637	96.2418	NM_032626
RBBP6	hsa-miR-6071	95.8824	NM_006910
RBBP6	hsa-miR-1283	94.8739	NM_032626
RBBP6	hsa-miR-4755-3p	94.1926	NM_006910
RBBP6	hsa-miR-148a-5p	94.1545	NM_032626
RBBP6	hsa-miR-23b-3p	94.0814	NM_006910
RBBP6	hsa-miR-23a-3p	94.0814	NM_006910
RBBP6	hsa-miR-23c	94.0814	NM_006910
RBBP6	hsa-miR-4673	93.1848	NM_006910
RBBP6	hsa-miR-4645-5p	93.1848	NM_006910
RBBP6	hsa-miR-5683	91.8908	NM_006910
RBBP6	hsa-miR-9-3p	90.549	NM_006910
RBBP6	hsa-miR-4699-3p	89.9659	NM_032626
RBBP6	hsa-miR-548c-3p	88.8558	NM_006910
RBBP6	hsa-miR-5006-5p	88.7227	NM_006910
RBBP6	hsa-miR-4528	88.4178	NM_006910
RBBP6	hsa-miR-15a-5p	88.4054	NM_006910
RBBP6	hsa-miR-16-5p	88.4054	NM_006910
RBBP6	hsa-miR-424-5p	88.4054	NM_006910
RBBP6	hsa-miR-497-5p	88.4054	NM_006910
RBBP6	hsa-miR-6838-5p	88.4054	NM_006910
RBBP6	hsa-miR-195-5p	88.4054	NM_006910
RBBP6	hsa-miR-15b-5p	88.4054	NM_006910
RBBP6	hsa-miR-4778-5p	87.8614	NM_006910
RBBP6	hsa-miR-5591-3p	87.393	NM_032626
RBBP6	hsa-miR-320b	86.0155	NM_006910
RBBP6	hsa-miR-320c	86.0155	NM_006910
RBBP6	hsa-miR-320a-3p	86.0155	NM_006910
RBBP6	hsa-miR-4429	86.0155	NM_006910
RBBP6	hsa-miR-320d	86.0155	NM_006910
RBBP6	hsa-let-7c-3p	85.573	NM_006910
RBBP6	hsa-miR-3671	85.3894	NM_006910
RBBP6	hsa-miR-3686	84.2595	NM_006910
RBBP6	hsa-miR-545-3p	84.2276	NM_006910
RBBP6	hsa-miR-4272	81.6468	NM_032626
RBBP6	hsa-miR-323a-3p	81.4973	NM_006910
RBBP6	hsa-miR-12129	80.2808	NM_032626
RBBP6	hsa-miR-660-5p	80.0044	NM_032626

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Motifs and transcription factors (TFs) regulating RBBP6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBBP6	transfac_pro__M04950	EGR1 (directAnnotation).
RBBP6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RBBP6	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
RBBP6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RBBP6	transfac_pro__M00652	NRF1 (directAnnotation).
RBBP6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RBBP6	transfac_pro__M04866	HDAC2 (directAnnotation).
RBBP6	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
RBBP6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RBBP6	transfac_pro__M01783	SP2 (directAnnotation).
RBBP6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RBBP6	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
RBBP6	transfac_pro__M01253	CNOT3 (directAnnotation).
RBBP6	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RBBP6	metacluster_7.13	ZFX (directAnnotation).
RBBP6	cisbp__M00968	MTF2 (directAnnotation).
RBBP6	transfac_pro__M04817	ZBTB33 (directAnnotation).
RBBP6	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
RBBP6	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RBBP6	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RBBP6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RBBP6	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RBBP6	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RBBP6	cisbp__M00788	ZFY (inferredBy_Orthology).
RBBP6	transfac_pro__M00430	E2F1 (directAnnotation).
RBBP6	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RBBP6	transfac_pro__M04893	TAF1 (directAnnotation).
RBBP6	transfac_pro__M01199	TRIM28 (directAnnotation).
RBBP6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RBBP6	hdpi__HIP2	UBE2K (directAnnotation).
RBBP6	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
RBBP6	hdpi__RARA	RARA (directAnnotation).
RBBP6	hdpi__ELF2	ELF2 (directAnnotation).
RBBP6	transfac_pro__M02898	SMAD3 (directAnnotation).
RBBP6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RBBP6	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RBBP6	transfac_pro__M04916	TAF1 (directAnnotation).
RBBP6	transfac_pro__M07310	SP5 (directAnnotation).
RBBP6	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RBBP6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RBBP6	metacluster_182.10	ZFX (directAnnotation).
RBBP6	hdpi__ZNF304	ZNF304 (directAnnotation).
RBBP6	metacluster_141.4	GLIS2 (directAnnotation).
RBBP6	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
RBBP6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RBBP6	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
RBBP6	transfac_public__M00024	E2F1 (directAnnotation).
RBBP6	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RBBP6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RBBP6	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."