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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RASSF6

Summary for RASSF6

Gene information	Gene symbol	RASSF6
	Ensembl ID	ENSG00000169435
	Entrez ID	166824
	Gene name	Ras association domain family member 6
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q6ZTQ3

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Dataset with differentially expressed gene: RASSF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.751771	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.440626	1.72e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.323063	2.43e-10

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Expression of RASSF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RASSF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RASSF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RASSF6	hsa-miR-5011-5p	99.8572	NM_001270392
RASSF6	hsa-miR-190a-3p	95.7498	NM_001270392
RASSF6	hsa-miR-9983-3p	95.4883	NM_001270392
RASSF6	hsa-miR-129-5p	94.8126	NM_001270392
RASSF6	hsa-miR-1277-5p	94.0604	NM_001270392
RASSF6	hsa-miR-205-3p	91.0944	NM_001270392
RASSF6	hsa-miR-153-5p	90.0276	NM_001270392
RASSF6	hsa-miR-6512-5p	89.645	NM_001270392
RASSF6	hsa-miR-5692c	89.5082	NM_001270392
RASSF6	hsa-miR-5692b	89.5082	NM_001270392
RASSF6	hsa-miR-7152-5p	89.3911	NM_001270392
RASSF6	hsa-miR-2054	88.9292	NM_001270391
RASSF6	hsa-miR-33a-3p	88.0993	NM_001270392
RASSF6	hsa-miR-203a-3p	87.2505	NM_001270392
RASSF6	hsa-miR-302f	85.9942	NM_001270392
RASSF6	hsa-miR-299-5p	84.6535	NM_001270392
RASSF6	hsa-miR-944	84.3628	NM_001270392
RASSF6	hsa-miR-4291	83.9701	NM_001270392
RASSF6	hsa-miR-335-3p	83.8353	NM_001270392
RASSF6	hsa-miR-5699-5p	83.3691	NM_001270392
RASSF6	hsa-miR-499b-5p	83.0969	NM_001270392
RASSF6	hsa-miR-3921	82.3058	NM_001270392
RASSF6	hsa-miR-4653-5p	82.3058	NM_001270392
RASSF6	hsa-miR-4795-3p	82.3007	NM_001270392
RASSF6	hsa-miR-12119	82.2797	NM_001270392
RASSF6	hsa-miR-203b-3p	81.5538	NM_001270392
RASSF6	hsa-miR-3152-5p	81.5424	NM_001270392
RASSF6	hsa-miR-411-3p	80.612	NM_001270392
RASSF6	hsa-miR-379-3p	80.612	NM_001270392

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Motifs and transcription factors (TFs) regulating RASSF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RASSF6	jaspar__MA1483.2	ELF2 (directAnnotation).
RASSF6	transfac_pro__M06564	ZNF578 (directAnnotation).
RASSF6	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
RASSF6	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
RASSF6	taipale_tf_pairs__HOXB2_ETV7_NSCGGAARNNNNNNMATTAN_CAP_repr	ETV7; HOXB2 (directAnnotation).
RASSF6	metacluster_134.1	ZFP69 (directAnnotation).
RASSF6	tfdimers__MD00018	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SPI1; SPIB; TAF6; TBP (directAnnotation).
RASSF6	transfac_pro__M05939	ZNF471 (directAnnotation).
RASSF6	tfdimers__MD00488	ELF1; HDX (directAnnotation).
RASSF6	transfac_public__M00039	CREB1 (directAnnotation).
RASSF6	tfdimers__MD00399	ELF5; NFATC3 (directAnnotation).
RASSF6	transfac_pro__M05447	INSM2 (inferredBy_Orthology).
RASSF6	tfdimers__MD00177	STAT1; TCF7L1 (directAnnotation).
RASSF6	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
RASSF6	tfdimers__MD00186	NFATC3; SPI1 (directAnnotation).
RASSF6	jaspar__MA1951.1	FOS (directAnnotation).
RASSF6	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."