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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RASSF5

Summary for RASSF5

Gene information	Gene symbol	RASSF5
	Ensembl ID	ENSG00000266094
	Entrez ID	83593
	Gene name	Ras association domain family member 5
	Synonyms	Maxp1\|NORE1\|RAPL
	Gene type	protein_coding
	UniProtAcc	Q8WWW0

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Dataset with differentially expressed gene: RASSF5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.2846	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.280425	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.27066	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.366679	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.27625	6.01e-28

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Expression of RASSF5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RASSF5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RASSF5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RASSF5	hsa-miR-548as-3p	97.2527	NM_182663
RASSF5	hsa-miR-532-5p	95.9221	NM_182664
RASSF5	hsa-miR-616-5p	95.9021	NM_182664
RASSF5	hsa-miR-373-5p	95.9021	NM_182664
RASSF5	hsa-miR-371b-5p	95.9021	NM_182664
RASSF5	hsa-miR-4324	95.8418	NM_182664
RASSF5	hsa-miR-5011-5p	95.8183	NM_182664
RASSF5	hsa-miR-4728-5p	92.5046	NM_182663
RASSF5	hsa-miR-1468-3p	92.3841	NM_182664
RASSF5	hsa-miR-507	92.2496	NM_182664
RASSF5	hsa-miR-320a-5p	91.7313	NM_182664
RASSF5	hsa-miR-6785-5p	91.3372	NM_182663
RASSF5	hsa-miR-5001-3p	90.7134	NM_182664
RASSF5	hsa-miR-6883-5p	90.1819	NM_182663
RASSF5	hsa-miR-149-3p	90.1819	NM_182663
RASSF5	hsa-miR-5692a	89.7821	NM_182664
RASSF5	hsa-miR-6868-3p	89.6291	NM_182664
RASSF5	hsa-miR-1286	88.4967	NM_182664
RASSF5	hsa-miR-548aw	88.3905	NM_182663
RASSF5	hsa-miR-4684-3p	87.7302	NM_182663
RASSF5	hsa-miR-557	87.6954	NM_182664
RASSF5	hsa-miR-450b-5p	87.639	NM_182664
RASSF5	hsa-miR-1200	87.0794	NM_182664
RASSF5	hsa-miR-5008-3p	85.4464	NM_182664
RASSF5	hsa-miR-7157-3p	85.4464	NM_182664
RASSF5	hsa-miR-6737-3p	85.4464	NM_182664
RASSF5	hsa-miR-367-5p	85.4336	NM_182663
RASSF5	hsa-miR-1237-3p	85.1619	NM_182664
RASSF5	hsa-miR-544b	84.9635	NM_182664
RASSF5	hsa-miR-4251	84.8272	NM_182664
RASSF5	hsa-miR-124-3p	84.1274	NM_182664
RASSF5	hsa-miR-506-3p	84.1274	NM_182664
RASSF5	hsa-miR-4297	83.8586	NM_182664
RASSF5	hsa-miR-3180-5p	82.5896	NM_182664
RASSF5	hsa-miR-3192-3p	82.2735	NM_182663
RASSF5	hsa-miR-511-3p	81.1083	NM_182663
RASSF5	hsa-miR-6721-5p	80.0805	NM_182663
RASSF5	hsa-miR-4753-3p	80.011	NM_182664

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Motifs and transcription factors (TFs) regulating RASSF5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RASSF5	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RASSF5	transfac_pro__M12697	ZNF142 (directAnnotation).
RASSF5	metacluster_198.3	ZFP64 (directAnnotation).
RASSF5	transfac_pro__M06488	ZNF595 (directAnnotation).
RASSF5	transfac_pro__M05463	ZIM2 (directAnnotation).
RASSF5	tfdimers__MD00187	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
RASSF5	hdpi__GTF3C2	GTF3C2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."