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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RASAL2

Summary for RASAL2

Gene information	Gene symbol	RASAL2
	Ensembl ID	ENSG00000075391
	Entrez ID	9462
	Gene name	RAS protein activator like 2
	Synonyms	nGAP
	Gene type	protein_coding
	UniProtAcc	Q9UJF2

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Dataset with differentially expressed gene: RASAL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.358367	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.368248	2.26e-36

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Expression of RASAL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RASAL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RASAL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RASAL2	hsa-miR-5011-5p	99.6991	NM_004841
RASAL2	hsa-miR-493-5p	99.192	NM_004841
RASAL2	hsa-miR-190a-3p	98.6004	NM_004841
RASAL2	hsa-miR-10399-5p	97.3278	NM_004841
RASAL2	hsa-miR-6504-3p	97.3278	NM_004841
RASAL2	hsa-miR-6859-5p	97.1449	NM_004841
RASAL2	hsa-miR-3125	97.1449	NM_004841
RASAL2	hsa-miR-3916	97.1449	NM_004841
RASAL2	hsa-miR-583	95.9709	NM_004841
RASAL2	hsa-miR-6809-3p	95.8801	NM_004841
RASAL2	hsa-miR-135b-5p	95.4928	NM_004841
RASAL2	hsa-miR-135a-5p	95.4928	NM_004841
RASAL2	hsa-miR-3686	94.9635	NM_004841
RASAL2	hsa-miR-3143	94.4055	NM_004841
RASAL2	hsa-miR-942-3p	94.1667	NM_004841
RASAL2	hsa-miR-3145-3p	93.973	NM_004841
RASAL2	hsa-miR-656-3p	93.8684	NM_004841
RASAL2	hsa-miR-345-3p	92.6937	NM_004841
RASAL2	hsa-miR-548at-5p	92.5784	NM_004841
RASAL2	hsa-miR-3658	92.4056	NM_004841
RASAL2	hsa-miR-561-3p	91.7434	NM_004841
RASAL2	hsa-miR-4652-3p	91.7301	NM_004841
RASAL2	hsa-miR-376c-3p	90.7864	NM_004841
RASAL2	hsa-miR-6868-3p	90.4654	NM_004841
RASAL2	hsa-miR-4516	89.8667	NM_004841
RASAL2	hsa-miR-4311	89.6097	NM_004841
RASAL2	hsa-miR-4308	89.1128	NM_004841
RASAL2	hsa-miR-874-3p	88.9972	NM_004841
RASAL2	hsa-miR-6855-5p	88.7861	NM_004841
RASAL2	hsa-miR-33a-3p	88.1976	NM_004841
RASAL2	hsa-miR-6839-5p	87.647	NM_004841
RASAL2	hsa-miR-543	87.4351	NM_004841
RASAL2	hsa-miR-3977	87.4157	NM_004841
RASAL2	hsa-miR-7976	87.3568	NM_004841
RASAL2	hsa-miR-6734-5p	86.5802	NM_004841
RASAL2	hsa-miR-3170	86.3544	NM_004841
RASAL2	hsa-miR-378j	86.2346	NM_004841
RASAL2	hsa-miR-302e	85.6254	NM_004841
RASAL2	hsa-miR-4795-3p	85.115	NM_004841
RASAL2	hsa-miR-26b-3p	84.9822	NM_004841
RASAL2	hsa-miR-548c-3p	84.7998	NM_004841
RASAL2	hsa-miR-4447	84.6552	NM_004841
RASAL2	hsa-miR-4703-5p	84.1891	NM_004841
RASAL2	hsa-miR-589-3p	84.0764	NM_004841
RASAL2	hsa-miR-4425	83.8835	NM_004841
RASAL2	hsa-miR-8065	83.697	NM_004841
RASAL2	hsa-miR-6785-3p	83.6391	NM_004841
RASAL2	hsa-miR-1290	83.6388	NM_004841
RASAL2	hsa-miR-6818-5p	83.5076	NM_004841
RASAL2	hsa-miR-5703	82.7216	NM_004841

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Motifs and transcription factors (TFs) regulating RASAL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RASAL2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RASAL2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RASAL2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RASAL2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RASAL2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RASAL2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RASAL2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RASAL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RASAL2	cisbp__M00968	MTF2 (directAnnotation).
RASAL2	cisbp__M00341	PAX6 (directAnnotation).
RASAL2	metacluster_198.3	ZFP64 (directAnnotation).
RASAL2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RASAL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RASAL2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RASAL2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RASAL2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RASAL2	hdpi__ZNF304	ZNF304 (directAnnotation).
RASAL2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RASAL2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RASAL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RASAL2	transfac_pro__M01199	TRIM28 (directAnnotation).
RASAL2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RASAL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RASAL2	transfac_pro__M03806	ZBTB7C (directAnnotation).
RASAL2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."