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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: RARA

Summary for RARA

Gene information	Gene symbol	RARA
	Ensembl ID	ENSG00000131759
	Entrez ID	5914
	Gene name	retinoic acid receptor alpha
	Synonyms	NR1B1\|RAR\|RAR-alpha\|RARalpha
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RARA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.493677	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.551322	0.00e+00

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Expression of RARA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RARA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RARA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RARA	hsa-miR-6867-5p	98.3446	NM_001145302
RARA	hsa-miR-138-5p	97.1264	NM_000964
RARA	hsa-miR-218-5p	91.7547	NM_001145302
RARA	hsa-miR-9985	90.1159	NM_000964
RARA	hsa-miR-27b-3p	90.1159	NM_000964
RARA	hsa-miR-27a-3p	90.1159	NM_000964
RARA	hsa-miR-4328	90.0396	NM_000964
RARA	hsa-miR-7110-5p	88.5213	NM_001145302
RARA	hsa-miR-6842-5p	88.5213	NM_001145302
RARA	hsa-miR-4763-3p	87.506	NM_001145302
RARA	hsa-miR-939-5p	87.0828	NM_001145302
RARA	hsa-miR-1343-5p	87.0828	NM_001145302
RARA	hsa-miR-6827-5p	86.6533	NM_000964
RARA	hsa-miR-4299	86.4673	NM_000964
RARA	hsa-miR-7851-3p	86.1859	NM_000964
RARA	hsa-miR-1207-5p	85.8821	NM_001145302
RARA	hsa-miR-216a-3p	84.919	NM_000964
RARA	hsa-miR-6752-5p	84.4466	NM_001145302
RARA	hsa-miR-3662	84.2527	NM_001145302
RARA	hsa-miR-6131	81.9355	NM_000964
RARA	hsa-miR-133a-5p	81.9355	NM_000964
RARA	hsa-miR-3613-3p	81.208	NM_001145302
RARA	hsa-miR-4728-5p	81.1968	NM_001145302
RARA	hsa-miR-128-3p	80.6799	NM_000964
RARA	hsa-miR-6852-5p	80.4376	NM_000964
RARA	hsa-miR-4447	80.353	NM_001145302

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Motifs and transcription factors (TFs) regulating RARA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RARA	jaspar__MA1721.1	ZNF93 (directAnnotation).
RARA	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RARA	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
RARA	transfac_pro__M07329	SP7 (directAnnotation).
RARA	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
RARA	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
RARA	metacluster_22.18	BACH2 (inferredBy_Orthology).
RARA	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
RARA	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
RARA	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
RARA	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
RARA	metacluster_22.32	NFE2L2 (directAnnotation).
RARA	metacluster_22.11	NFE2 (directAnnotation).
RARA	metacluster_167.7	IRF8 (inferredBy_Orthology).
RARA	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
RARA	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
RARA	transfac_pro__M06404	ZNF497 (directAnnotation).
RARA	metacluster_22.37	BACH1 (directAnnotation).
RARA	metacluster_22.17	NFE2 (directAnnotation).
RARA	metacluster_38.1	ETV7; ETV7; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT4; STAT5A; STAT5B (directAnnotation). STAT1; STAT3; STAT3; STAT4; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
RARA	cisbp__M01816	JUN (inferredBy_Orthology).
RARA	transfac_pro__M01239	RELA (directAnnotation).
RARA	swissregulon__hs__RUNX2	RUNX2 (directAnnotation).
RARA	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
RARA	transfac_pro__M05397	ZNF444 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
RARA	metacluster_196.3	down	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RARA	"Acitretin"	DB00459	small molecule
RARA	"Adapalene"	DB00210	small molecule
RARA	"Alitretinoin"	DB00523	small molecule
RARA	"Etretinate"	DB00926	small molecule
RARA	"Isotretinoin"	DB00982	small molecule
RARA	"LGD-1550"	DB05785	small molecule
RARA	"Tamibarotene"	DB04942	small molecule
RARA	"Tazarotene"	DB00799	small molecule
RARA	"Tretinoin"	DB00755	small molecule
RARA	"Trifarotene"	DB12808	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."