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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAPGEF5

Summary for RAPGEF5

Gene information	Gene symbol	RAPGEF5
	Ensembl ID	ENSG00000136237
	Entrez ID	9771
	Gene name	Rap guanine nucleotide exchange factor 5
	Synonyms	GFR\|KIAA0277\|MR-GEF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAPGEF5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.773055	1.15e-03

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Expression of RAPGEF5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAPGEF5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAPGEF5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAPGEF5	hsa-miR-182-5p	98.4914	NM_012294
RAPGEF5	hsa-miR-510-3p	97.7923	NM_012294
RAPGEF5	hsa-miR-5011-5p	96.654	NM_012294
RAPGEF5	hsa-miR-4319	95.352	NM_012294
RAPGEF5	hsa-miR-125a-5p	94.3539	NM_012294
RAPGEF5	hsa-miR-125b-5p	94.3539	NM_012294
RAPGEF5	hsa-miR-6842-3p	94.1156	NM_012294
RAPGEF5	hsa-miR-190a-3p	94.0247	NM_012294
RAPGEF5	hsa-miR-6124	94.0043	NM_012294
RAPGEF5	hsa-miR-656-3p	93.6565	NM_012294
RAPGEF5	hsa-miR-137-3p	92.6641	NM_012294
RAPGEF5	hsa-miR-302b-5p	91.7407	NM_012294
RAPGEF5	hsa-miR-494-3p	91.6147	NM_012294
RAPGEF5	hsa-miR-4672	90.8408	NM_012294
RAPGEF5	hsa-miR-302d-5p	90.807	NM_012294
RAPGEF5	hsa-miR-1279	90.4934	NM_012294
RAPGEF5	hsa-miR-548ar-3p	90.4166	NM_012294
RAPGEF5	hsa-miR-2114-5p	90.0066	NM_012294
RAPGEF5	hsa-miR-1185-1-3p	88.06	NM_012294
RAPGEF5	hsa-miR-1185-2-3p	88.06	NM_012294
RAPGEF5	hsa-let-7f-2-3p	88.06	NM_012294
RAPGEF5	hsa-miR-3148	87.773	NM_012294
RAPGEF5	hsa-miR-5580-5p	86.6696	NM_012294
RAPGEF5	hsa-miR-4490	86.6634	NM_012294
RAPGEF5	hsa-miR-4685-5p	86.4609	NM_012294
RAPGEF5	hsa-miR-6837-5p	86.4609	NM_012294
RAPGEF5	hsa-miR-548a-3p	85.9496	NM_012294
RAPGEF5	hsa-miR-548bc	85.7118	NM_012294
RAPGEF5	hsa-miR-548az-3p	85.7118	NM_012294
RAPGEF5	hsa-miR-548e-3p	85.7118	NM_012294
RAPGEF5	hsa-miR-548f-3p	85.7118	NM_012294
RAPGEF5	hsa-miR-345-3p	85.0582	NM_012294
RAPGEF5	hsa-miR-4732-3p	85.0582	NM_012294
RAPGEF5	hsa-miR-9851-5p	84.9239	NM_012294
RAPGEF5	hsa-miR-5582-3p	84.4753	NM_012294
RAPGEF5	hsa-miR-1914-5p	84.0061	NM_012294
RAPGEF5	hsa-miR-200a-3p	83.7608	NM_012294
RAPGEF5	hsa-miR-141-3p	83.7608	NM_012294
RAPGEF5	hsa-miR-491-3p	83.4081	NM_012294
RAPGEF5	hsa-miR-548an	83.2131	NM_012294
RAPGEF5	hsa-miR-4478	83.1922	NM_012294
RAPGEF5	hsa-miR-4661-5p	82.82	NM_012294
RAPGEF5	hsa-miR-3187-3p	82.509	NM_012294
RAPGEF5	hsa-miR-4505	82.0323	NM_012294
RAPGEF5	hsa-miR-4728-3p	81.6959	NM_012294
RAPGEF5	hsa-miR-381-3p	81.0957	NM_012294
RAPGEF5	hsa-miR-300	81.0957	NM_012294
RAPGEF5	hsa-miR-5001-3p	81.0802	NM_012294
RAPGEF5	hsa-miR-8063	80.8337	NM_012294
RAPGEF5	hsa-miR-5787	80.2398	NM_012294

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Motifs and transcription factors (TFs) regulating RAPGEF5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAPGEF5	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RAPGEF5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAPGEF5	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RAPGEF5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RAPGEF5	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAPGEF5	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RAPGEF5	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RAPGEF5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAPGEF5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAPGEF5	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAPGEF5	transfac_pro__M07436	WT1 (directAnnotation).
RAPGEF5	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAPGEF5	transfac_pro__M00716	ZBTB14 (directAnnotation).
RAPGEF5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAPGEF5	hdpi__HIP2	UBE2K (directAnnotation).
RAPGEF5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RAPGEF5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAPGEF5	transfac_pro__M04893	TAF1 (directAnnotation).
RAPGEF5	transfac_pro__M03876	ZBTB33 (directAnnotation).
RAPGEF5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RAPGEF5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAPGEF5	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAPGEF5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAPGEF5	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."