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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAP2C

Summary for RAP2C

Gene information	Gene symbol	RAP2C
	Ensembl ID	ENSG00000123728
	Entrez ID	57826
	Gene name	RAP2C, member of RAS oncogene family
	Synonyms	DKFZp313B211
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAP2C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.254715	1.36e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.262069	1.01e-16

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Expression of RAP2C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAP2C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAP2C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAP2C	hsa-miR-524-5p	99.7238	NM_001271186
RAP2C	hsa-miR-520d-5p	99.7238	NM_001271186
RAP2C	hsa-miR-551b-5p	99.5791	NM_001271186
RAP2C	hsa-miR-454-3p	98.9644	NM_001271186
RAP2C	hsa-miR-130a-3p	98.8954	NM_001271186
RAP2C	hsa-miR-301b-3p	98.8625	NM_001271186
RAP2C	hsa-miR-3666	98.8625	NM_001271186
RAP2C	hsa-miR-4295	98.8625	NM_001271186
RAP2C	hsa-miR-301a-3p	98.8625	NM_001271186
RAP2C	hsa-miR-130b-3p	98.8625	NM_001271186
RAP2C	hsa-miR-1537-5p	98.7046	NM_001271186
RAP2C	hsa-miR-548an	98.1639	NM_001271186
RAP2C	hsa-miR-4511	97.9086	NM_001271186
RAP2C	hsa-miR-145-3p	97.7673	NM_001271186
RAP2C	hsa-miR-19a-3p	96.0384	NM_001271186
RAP2C	hsa-miR-19b-3p	96.0384	NM_001271186
RAP2C	hsa-miR-200c-3p	95.7287	NM_001271186
RAP2C	hsa-miR-429	95.7287	NM_001271186
RAP2C	hsa-miR-200b-3p	95.7287	NM_001271186
RAP2C	hsa-miR-4698	95.4917	NM_001271186
RAP2C	hsa-miR-101-3p	95.3393	NM_001271186
RAP2C	hsa-miR-1297	95.2884	NM_001271186
RAP2C	hsa-miR-8067	95.2797	NM_001271186
RAP2C	hsa-miR-6890-3p	95.2348	NM_001271186
RAP2C	hsa-miR-6508-5p	95.2331	NM_001271186
RAP2C	hsa-miR-6832-3p	95.0998	NM_001271186
RAP2C	hsa-miR-30d-5p	95.0203	NM_001271186
RAP2C	hsa-miR-30e-5p	95.0203	NM_001271186
RAP2C	hsa-miR-30b-5p	95.0203	NM_001271186
RAP2C	hsa-miR-30a-5p	95.0203	NM_001271186
RAP2C	hsa-miR-30c-5p	95.0203	NM_001271186
RAP2C	hsa-miR-6869-5p	94.5896	NM_001271186
RAP2C	hsa-miR-548e-5p	94.5786	NM_001271186
RAP2C	hsa-miR-181b-2-3p	94.5357	NM_001271186
RAP2C	hsa-miR-181b-3p	94.5357	NM_001271186
RAP2C	hsa-miR-4420	94.5357	NM_001271186
RAP2C	hsa-miR-1252-3p	94.4481	NM_001271186
RAP2C	hsa-miR-651-3p	94.2479	NM_001271186
RAP2C	hsa-miR-892c-5p	93.9569	NM_001271186
RAP2C	hsa-miR-548aw	93.8303	NM_001271186
RAP2C	hsa-miR-4635	93.6825	NM_001271186
RAP2C	hsa-miR-26a-5p	93.5492	NM_001271186
RAP2C	hsa-miR-26b-5p	93.5492	NM_001271186
RAP2C	hsa-miR-4762-5p	92.9017	NM_001271186
RAP2C	hsa-miR-20a-5p	92.6285	NM_001271186
RAP2C	hsa-miR-106b-5p	92.6285	NM_001271186
RAP2C	hsa-miR-4465	92.5802	NM_001271186
RAP2C	hsa-miR-607	92.4113	NM_001271186
RAP2C	hsa-miR-17-5p	92.3686	NM_001271186
RAP2C	hsa-miR-526b-3p	92.3686	NM_001271186

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Motifs and transcription factors (TFs) regulating RAP2C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAP2C	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RAP2C	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RAP2C	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RAP2C	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RAP2C	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RAP2C	jaspar__MA1483.2	ELF2 (directAnnotation).
RAP2C	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RAP2C	transfac_pro__M04826	EP300 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RAP2C	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RAP2C	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RAP2C	hdpi__ETV4	ETV4 (directAnnotation).
RAP2C	cisbp__M02645	ETS1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RAP2C	cisbp__M08198	ELF1 (directAnnotation).
RAP2C	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
RAP2C	jaspar__MA1708.1	ETV7 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RAP2C	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAP2C	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RAP2C	hdpi__TP73	TP73 (directAnnotation).
RAP2C	hdpi__ELF2	ELF2 (directAnnotation).
RAP2C	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
RAP2C	metacluster_183.4	ETS1 (inferredBy_Orthology).
RAP2C	transfac_pro__M01298	MECP2 (directAnnotation).
RAP2C	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
RAP2C	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
RAP2C	hdpi__FLI1	FLI1 (directAnnotation).
RAP2C	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RAP2C	transfac_pro__M04862	NRF1 (directAnnotation).
RAP2C	transfac_pro__M00492	STAT1 (directAnnotation).
RAP2C	transfac_pro__M04848	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."