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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RALGAPA1

Summary for RALGAPA1

Gene information	Gene symbol	RALGAPA1
	Ensembl ID	ENSG00000174373
	Entrez ID	253959
	Gene name	Ral GTPase activating protein catalytic subunit alpha 1
	Synonyms	DKFZp667F074\|GARNL1\|GRIPE\|KIAA0884\|RalGAPalpha1\|Tulip1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RALGAPA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.266344	2.08e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.479736	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.376431	7.01e-45
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.281248	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.314433	1.00e-30
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.33944	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.58296	0.00e+00

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Expression of RALGAPA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RALGAPA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RALGAPA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RALGAPA1	hsa-miR-372-5p	93.3301	NM_194301
RALGAPA1	hsa-miR-4668-5p	92.1758	NM_194301
RALGAPA1	hsa-miR-466	92.151	NM_194301
RALGAPA1	hsa-miR-187-5p	91.8138	NM_194301
RALGAPA1	hsa-miR-5701	91.2438	NM_194301
RALGAPA1	hsa-miR-4643	89.3285	NM_194301
RALGAPA1	hsa-miR-3675-5p	88.365	NM_194301
RALGAPA1	hsa-miR-151b	87.4608	NM_001283043
RALGAPA1	hsa-miR-151a-5p	87.4608	NM_001283043
RALGAPA1	hsa-miR-199a-5p	87.0069	NM_194301
RALGAPA1	hsa-miR-199b-5p	87.0069	NM_194301
RALGAPA1	hsa-miR-3148	86.9425	NM_194301
RALGAPA1	hsa-miR-5692a	86.916	NM_194301
RALGAPA1	hsa-miR-95-5p	86.8455	NM_194301
RALGAPA1	hsa-miR-190a-3p	86.3974	NM_194301
RALGAPA1	hsa-miR-624-5p	84.5852	NM_194301
RALGAPA1	hsa-miR-6083	83.975	NM_194301
RALGAPA1	hsa-miR-8084	83.6451	NM_194301
RALGAPA1	hsa-miR-449c-3p	83.0611	NM_001283043
RALGAPA1	hsa-miR-330-5p	82.3255	NM_001283043
RALGAPA1	hsa-miR-3662	81.1252	NM_194301
RALGAPA1	hsa-miR-6079	81.0593	NM_194301
RALGAPA1	hsa-miR-6507-5p	81.0203	NM_194301
RALGAPA1	hsa-miR-4284	80.1244	NM_194301
RALGAPA1	hsa-miR-3074-3p	80.049	NM_194301

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Motifs and transcription factors (TFs) regulating RALGAPA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RALGAPA1	transfac_pro__M01861	ATF1 (directAnnotation).
RALGAPA1	metacluster_52.11	ZNF184 (directAnnotation).
RALGAPA1	metacluster_98.1	ZNF524 (directAnnotation).
RALGAPA1	transfac_pro__M00514	ATF4 (directAnnotation).
RALGAPA1	cisbp__M00809	PRDM11 (inferredBy_Orthology).
RALGAPA1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
RALGAPA1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RALGAPA1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
RALGAPA1	transfac_pro__M04893	TAF1 (directAnnotation).
RALGAPA1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
RALGAPA1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RALGAPA1	cisbp__M00343	PAX6 (directAnnotation).
RALGAPA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RALGAPA1	transfac_public__M00039	CREB1 (directAnnotation).
RALGAPA1	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
RALGAPA1	hdpi__TIMELESS	TIMELESS (directAnnotation).
RALGAPA1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
RALGAPA1	transfac_pro__M01864	ATF4 (directAnnotation).
RALGAPA1	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
RALGAPA1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
RALGAPA1	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
RALGAPA1	transfac_pro__M00691	ATF1 (directAnnotation).
RALGAPA1	transfac_pro__M06208	ZNF460 (directAnnotation).
RALGAPA1	transfac_pro__M04746	E2F1 (directAnnotation).
RALGAPA1	transfac_public__M00041	ATF2; JUN (directAnnotation).
RALGAPA1	transfac_pro__M02279	CREB1 (directAnnotation).
RALGAPA1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
RALGAPA1	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
RALGAPA1	transfac_public__M00040	ATF2 (directAnnotation).
RALGAPA1	transfac_pro__M08803	CREM (directAnnotation).
RALGAPA1	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
RALGAPA1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RALGAPA1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
RALGAPA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RALGAPA1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RALGAPA1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."